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Titolo:
STIMULATION OF THE NIGROSTRIATAL DOPAMINE SYSTEM PRODUCES HYPERTENSION AND TACHYCARDIA IN RATS
Autore:
LIN MT; YANG JJ;
Indirizzi:
NATL CHENG KUNG UNIV,COLL MED,DEPT PHYSIOL TAINAN 70101 TAIWAN
Titolo Testata:
The American journal of physiology
fascicolo: 6, volume: 266, anno: 1994,
parte:, 2
pagine: 80002489 - 80002496
SICI:
0002-9513(1994)266:6<80002489:SOTNDS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINOAORTIC-DENERVATED RATS; CARBON-FIBER ELECTRODES; VOLTAMMETRY; RELEASE;
Keywords:
DOPAMINE; CORPUS STRIATUM; VOLTAMMETRY; SUBSTANTIA NIGRA; 6-HYDROXYDOPAMINE; HALOPERIDOL; PIMOZIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Lin e J.J. Yang, "STIMULATION OF THE NIGROSTRIATAL DOPAMINE SYSTEM PRODUCES HYPERTENSION AND TACHYCARDIA IN RATS", The American journal of physiology, 266(6), 1994, pp. 80002489-80002496

Abstract

To test for the ability of the nigrostriatal dopamine (DA) system to influence cardiovascular function, experiments were carried out to assess the effects of electrical or chemical stimulation of the nigrostriatal DA system on arterial blood pressure, heart rate, and striatal DArelease in anesthetized rats. Electrical stimulation of the substantia nigra pars compacta (SNC), in addition to enhancing the DA release in the corpus striatum (CS), elicited proportional hypertension and tachycardia. This could be mimicked by microinjection of two excitatory amino acids, kainic acid and glutamate, into the SNC area of rat brain. The SNC stimulation-induced hypertension, tachycardia, and increased striatal DA release were attenuated by prior destruction of the nigrostriatal DA system produced by intramedial forebrain bundle injection of 6-hydroxydopamine and by prior blockade of postsynaptic DA receptorsproduced by intra-CS injection of DA receptor antagonists, haloperidol or pimozide. The SNC stimulation-induced hypertension was attenuatedby spinal transection, whereas the SNC stimulation-induced tachycardia was attenuated by bilateral vagotomy. The data suggest that stimulation of the nigrostriatal DA system produces both hypertension and tachycardia in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:38:24