Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACETAMINOPHEN BLOCKS SPINAL HYPERALGESIA INDUCED BY NMDA AND SUBSTANCE-P
Autore:
BJORKMAN R; HALLMAN KM; HEDNER J; HEDNER T; HENNING M;
Indirizzi:
GOTHENBURG UNIV,DEPT PHARMACOL,MEDICINARGATAN 7 S-41390 GOTHENBURG SWEDEN GOTHENBURG UNIV,DEPT CLIN PHARMACOL GOTHENBURG SWEDEN SAHLGRENS UNIV HOSP S-41345 GOTHENBURG SWEDEN
Titolo Testata:
Pain
fascicolo: 3, volume: 57, anno: 1994,
pagine: 259 - 264
SICI:
0304-3959(1994)57:3<259:ABSHIB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; SOLUBLE GUANYLATE-CYCLASE; NITRIC-OXIDE; CHRONIC CATHETERIZATION; SUBARACHNOID SPACE; NERVOUS-SYSTEM; RAT; NEURONS; PARACETAMOL; GLUTAMATE;
Keywords:
N-METHYL-D-ASPARTATE; NITRIC OXIDE; ACETAMINOPHEN; NOCICEPTION; HYPERALGESIA; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
R. Bjorkman et al., "ACETAMINOPHEN BLOCKS SPINAL HYPERALGESIA INDUCED BY NMDA AND SUBSTANCE-P", Pain, 57(3), 1994, pp. 259-264

Abstract

The hypothesis tested was that inhibition of the L-arginine-nitric oxide (NO) pathway may represent a potential central mechanism of actionfor acetaminophen (paracetamol). Spinal administration of N-methyl-D-aspartate (NMDA, 0.5 nmol), pha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA, 0:1 nmol) or substance P (SP, 0.5 nmol) to the rat provoked a specific behaviour characterized by biting, scratching and licking (BSL). This behaviour was antagonized by pretreatment with acetaminophen for NMDA and SP but not for AMPA. Further, the antinociceptiveeffect of acetaminophen was readily reversed by administration of thenatural substrate for nitric oxide synthase (NOS), L-arginine, but not by D-arginine. This suggests that the analgesic effect of acetaminophen is related to inhibition of NO generation. Potential mechanisms for this may involve NMDA and SP. Our data suggest that a significant portion of the analgesic effect of acetaminophen, when used clinically, may be related to an interaction with the central nervous system L-arginine-NO pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 13:30:31