Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SELECTIVE MYCOBACTERIUM AVIUM-INDUCED PRODUCTION OF NITRIC-OXIDE BY HUMAN MONOCYTE-DERIVED MACROPHAGES
Autore:
DUMAREY CH; LABROUSSE V; RASTOGI N; VARGAFTIG BB; BACHELET M;
Indirizzi:
INST PASTEUR,INSERM,U285,UNITE PHARMACOL CELLULAIRE,25 RUE DR ROUX F-75724 PARIS 15 FRANCE INST PASTEUR,INSERM,U285,UNITE PHARMACOL CELLULAIRE F-75724 PARIS 15 FRANCE INST PASTEUR,UNITE TB & MYCOBACTERIES PARIS FRANCE
Titolo Testata:
Journal of leukocyte biology
fascicolo: 1, volume: 56, anno: 1994,
pagine: 36 - 40
SICI:
0741-5400(1994)56:1<36:SMAPON>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MONONUCLEAR PHAGOCYTES; L-ARGININE; PERITONEAL-MACROPHAGES; MURINE MACROPHAGES; INTERFERON-GAMMA; IFN-GAMMA; SYNTHASE; MECHANISMS; PATHWAY; BIOSYNTHESIS;
Keywords:
NITRIC OXIDE; HUMAN MONOCYTE-DERIVED MACROPHAGES; MYCOBACTERIA; MYCOBACTERIUM-AVIUM; MYCOBACTERIUM-TUBERCULOSIS; MYCOBACTERIUM-SMEGMATIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
C.H. Dumarey et al., "SELECTIVE MYCOBACTERIUM AVIUM-INDUCED PRODUCTION OF NITRIC-OXIDE BY HUMAN MONOCYTE-DERIVED MACROPHAGES", Journal of leukocyte biology, 56(1), 1994, pp. 36-40

Abstract

Infection with a virulent strain of Mycobacterium avium, but not withvirulent Mycobacterium tuberculosis or avirulent Mycobacterium smegmatis, induced the formation of nitric oxide by human monocyte-derived macrophages. This process was not affected by lipopolysaccharide or cytokines such as interferon-gamma or tumor necrosis factor alpha. M. avium-induced nitric oxide production was significantly decreased by N-G-monomethyl-L-arginine, a potent inhibitor of nitric oxide synthase activity, without any significant enhancement of intramacrophagic mycobacterial growth. Infection with all the three mycobacterial species induced a significant activation of phospholipase A(2) activity of macrophages as evidenced by the increased release of thromboxane A(2). Finally, nitric oxide production by human monocyte-derived macrophages required infection with live M. avium, as neither gamma-irradiated M. aviumnor the subcellular fractions of this microorganism (cell wall, cytosol) were able to trigger nitric oxide synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 14:25:29