Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AN ESSENTIAL ROLE FOR FREE-RADICALS AND DERIVED SPECIES IN SIGNAL-TRANSDUCTION
Autore:
LANDER HM;
Indirizzi:
CORNELL UNIV,COLL MED,DEPT BIOCHEM,1300 YORK AVE NEW YORK NY 10021
Titolo Testata:
The FASEB journal
fascicolo: 2, volume: 11, anno: 1997,
pagine: 118 - 124
SICI:
0892-6638(1997)11:2<118:AERFFA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; VASCULAR SMOOTH-MUSCLE; NITRIC-OXIDE; GROWTH-FACTOR; TRANSCRIPTION FACTOR; IN-VITRO; TYROSINE PHOSPHORYLATION; HYDROGEN-PEROXIDE; OXIDATIVE-STRESS; OXYGEN RADICALS;
Keywords:
INTRACELLULAR MESSENGER; PDGF; REACTIVE OXYGEN SPECIES; SPECIFICITY REGULATION; REACTIVE NITROGEN SPECIES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
90
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Lander, "AN ESSENTIAL ROLE FOR FREE-RADICALS AND DERIVED SPECIES IN SIGNAL-TRANSDUCTION", The FASEB journal, 11(2), 1997, pp. 118-124

Abstract

It is well accepted that extracellular ligands trigger nuclear signals through a cascade of protein-protein interactions, Many of these pathways have been carefully defined and provide an important framework by which we can understand and intervene in the processes they initiate. Recent data in the literature indicate that really extracellular Ligands generate and/or require reactive free radicals or derived speciesto successfully transmit their signals to the nucleus. Thus, a novel signaling mechanism akin to one solely dependent on protein-protein interactions may exist, Here, TI-e review this information, identify both the sources and targets of free radicals generated by various growthfactors and cytokines, discuss how specificity call be achieved, and explore the pathophysiological implications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:20:39