Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PROTEIN-S AND PROTEIN-C ANTICOAGULANT ACTIVITY IN ACUTE AND CHRONIC CARDIAC ISCHEMIC SYNDROMES - RELATIONSHIP TO INFLAMMATION, COMPLEMENT ACTIVATION AND IN-VIVO THROMBIN ACTIVITY
Autore:
DANGELO A; GEROSA S; DANGELO SV; MAILHAC A; COLOMBO A; AGAZZI A; MAZZOLA G; CHIERCHIA S;
Indirizzi:
HOSP SAN RAFFAELE,IRCCS,COAGULAT SERV,VIA OLGETTINA 60 I-20132 MILAN ITALY HOSP SAN RAFFAELE,IRCCS,DEPT CARDIOL I-20132 MILAN ITALY
Titolo Testata:
Thrombosis research
fascicolo: 2, volume: 75, anno: 1994,
pagine: 133 - 142
SICI:
0049-3848(1994)75:2<133:PAPAAI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY DISEASE; HEART-DISEASE; FACTOR-VIII; INTRAVASCULAR COAGULATION; ORAL ANTICOAGULATION; VONWILLEBRAND-FACTOR; C4B-BINDING PROTEIN; FIBRINOPEPTIDE-A; UNSTABLE ANGINA;
Keywords:
ISCHEMIC HEART DISEASE; PROTEIN S; THROMBIN-ANTITHROMBIN COMPLEX; HYPERCOAGULABILITY; VITAMIN-K-DEPENDENT FACTORS; VON WILLEBRAND FACTOR; COMPLEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
A. Dangelo et al., "PROTEIN-S AND PROTEIN-C ANTICOAGULANT ACTIVITY IN ACUTE AND CHRONIC CARDIAC ISCHEMIC SYNDROMES - RELATIONSHIP TO INFLAMMATION, COMPLEMENT ACTIVATION AND IN-VIVO THROMBIN ACTIVITY", Thrombosis research, 75(2), 1994, pp. 133-142

Abstract

Protein S (PS) and protein C (PC) anticoagulant activities and thrombin-antithrombin complex (TAT) were measured in 20 patients with AIS, 25 patients with chronic stable angina (CSA) and a control group (C). Although plasma levels of TAT were significantly elevated in patients with CSA (p < 0.01 vs C), they were much higher in patients with AIS (p< 0.001 vs CSA). PC anticoagulant activity was similar in patients and controls. At variance, PS anticoagulant activity was lower in patients with AIS than in those with CSA and controls (p < 0.05), reflectingdifferences in total PS and C4B-binding protein (C4B-BP) antigen possible resulting from involvement in the mechanisms of inflammation, complement activation and acute-phase response. The ratios of anticoagulant PS and PC to procoagulant vitamin K-dependent factors IX and II were reduced in AIS patients (0.05 > p > 0.005 vs C). In addition, the ratios of anticoagulant PC and PS to factor IX were lower in patients with AIS than in those with CSA (p < 0.05). These results indicate that in patients with acute ischemic cardiac syndromes the markedly increased in vivo thrombin generation is associated with an unbalance betweencoagulant and anticoagulant vitamin K-dependent factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 10:07:30