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Titolo:
SUDDEN AND UNEXPECTED DEATH IN CLINICALLY SILENT CHAGAS-DISEASE - A HYPOTHESIS
Autore:
BAROLDI G; OLIVEIRA SJM; SILVER MD;
Indirizzi:
OSPED MAGGIORE NIGUARDA,DIPARTIMENTO CARDIOL GASPERIS,CNR,IST FISIOL CLIN,PZA OSPED MAGGIORE MILAN 3 ITALY NIGUARDA HOSP,DEPT CARDIOL,CNR,INST CLIN PHYSIOL MILAN ITALY UNIV MILAN,L SACCO HOSP VIALBA,INST PATHOL ANAT,INST BIOMED SCI MILANITALY UNIV SAO PAULO,FAC MED,DEPT PATHOL RIBEIRAO PRET BRAZIL UNIV TORONTO,FAC MED TORONTO ON CANADA TORONTO HOSP,DEPT PATHOL TORONTO ON M5T 2S8 CANADA
Titolo Testata:
International journal of cardiology
fascicolo: 3, volume: 58, anno: 1997,
pagine: 263 - 268
SICI:
0167-5273(1997)58:3<263:SAUDIC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-SYNDROME AIDS; MYOCARDIUM; HEART;
Keywords:
HEART CHAGAS DISEASE; SUDDEN/UNEXPECTED DEATH; CATECHOLAMINE CARDIOTOXICITY; MYOCARDITIS; COAGULATIVE; MYOCYTOLYSIS; CONTRACTION BAND NECROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
G. Baroldi et al., "SUDDEN AND UNEXPECTED DEATH IN CLINICALLY SILENT CHAGAS-DISEASE - A HYPOTHESIS", International journal of cardiology, 58(3), 1997, pp. 263-268

Abstract

Background: Chagas' heart disease presents an interesting model of cardiac autonomic nerve dysfunction associated with morphologic lesions. A lack of quantitative evaluation of the latter suggested this study in which hearts from 34 subjects who were serum-positive for Chagas' disease but had no clinical evidence of it and who died suddenly and unexpectedly, out-of-hospital, were examined. Methods and Results: By systematic myocardial sampling the histologic area was measured to establish: (a) the number of focal lymphocytic infiltratesx100 mm(2) and average number of lymphocytes per focus; (b) number of foci of, and myocells with, coagulative myocytolysis (contraction band necrosis) x100 mm(2); and (c) the percentage of substitutive myocardial fibrosis. In all cases findings were: (a) intermyocellular lymphocytic infiltrates (6+/-6 focix100 mm(2)); (b) coagulative myocytolysis (3+/-5 foci and 26/-56 myocellsx100 mm(2)). Conclusions: In all 34 subjects quantitative analysis showed extensive lymphocytic infiltrates and myocardial damage typical of catecholamine cardiotoxicity. These two acute or activehistological changes may explain their sudden demise produced by focal denervation with regional asynergy and consequent compensatory adrenergic stimulus with myotoxicity and malignant arrhythmia. Copyright (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 22:33:47