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Titolo:
PRIMARY BILIARY-CIRRHOSIS - PREDICTION OF SHORT-TERM SURVIVAL BASED ON REPEATED PATIENT VISITS
Autore:
MURTAUGH PA; DICKSON ER; VANDAM GM; MALINCHOC M; GRAMBSCH PM; LANGWORTHY AL; GIPS CH;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV GASTROENTEROL & INTERNAL MED,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DIV GASTROENTEROL & INTERNAL MED ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,BIOSTAT SECT ROCHESTER MN 55905 UNIV GRONINGEN HOSP,DEPT INTERNAL MED 9700 RB GRONINGEN NETHERLANDS
Titolo Testata:
Hepatology
fascicolo: 1, volume: 20, anno: 1994,
parte:, 1
pagine: 126 - 134
SICI:
0270-9139(1994)20:1<126:PB-POS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-TRANSPLANTATION; PROGNOSTIC MODELS; REGRESSION-MODEL; VARIABLES; TRIAL; TIME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Murtaugh et al., "PRIMARY BILIARY-CIRRHOSIS - PREDICTION OF SHORT-TERM SURVIVAL BASED ON REPEATED PATIENT VISITS", Hepatology, 20(1), 1994, pp. 126-134

Abstract

The progression of primary biliary cirrhosis was studied in 312 patients who were seen at the Mayo Clinic between January 1974 and May 1984. Follow-up was extended to April 30, 1988, by which time 140 of the patients had died and 29 had undergone orthotopic liver transplantation. These patients generated 1,945 patient visits that enabled us to study the change in the prognostic variables of primary biliary cirrhosis(age, bilirubin value, albumin value, prothrombin time and edema) from the time of referral. Also, using this database and the Cox proportional-hazards regression model, we developed an updated model for primary biliary cirrhosis that can be used to predict short-term survival at any time in the course of the disease. This model uses the values ofthe prognostic variables measured at the latest patient visit. Comparison of predicted survival from the update model and the natural history model of primary biliary cirrhosis showed that the updated model was superior to the original model for predicting short-term survival. This finding applied to both the Mayo Clinic patients and an independent set of 83 Dutch patients. The Mayo updated model is recommended for improving the accuracy of predictions of survival during the 2 yr after a patient visit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:00:10