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Titolo:
PITUITARY-GONADAL INTERACTIONS IN PERINATAL RATS - RELATIONSHIPS OF PLASMA LUTEINIZING-HORMONE AND TESTOSTERONE CONCENTRATIONS, AND PITUITARY LEVELS OF LH SUBUNIT MESSENGER-RNAS
Autore:
PAKARINEN P; PROSHLYAKOVA E; HUHTANIEMI I;
Indirizzi:
UNIV TURKU,DEPT PHYSIOL,KIINAMYLLYNKATU 10 SF-20520 TURKU FINLAND RUSSIAN ACAD SCI,INST DEV BIOL MOSCOW 117808 RUSSIA
Titolo Testata:
Neuroendocrinology
fascicolo: 1, volume: 60, anno: 1994,
pagine: 42 - 49
SICI:
0028-3835(1994)60:1<42:PIIPR->2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; MESSENGER-RNA LEVELS; ETHANE DIMETHANE SULFONATE; FEMALE RATS; FETAL RATS; TESTICULAR STEROIDOGENESIS; FEEDBACK-REGULATION; GENE-EXPRESSION; NEONATAL RATS; LEYDIG-CELLS;
Keywords:
IMMUNOFLUOROMETRIC ASSAY; LUTEINIZING HORMONE; RAT; FETUS; FEEDBACK; TESTIS; PITUITARY; MESSENGER RNA; GONADOTROPINS; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
P. Pakarinen et al., "PITUITARY-GONADAL INTERACTIONS IN PERINATAL RATS - RELATIONSHIPS OF PLASMA LUTEINIZING-HORMONE AND TESTOSTERONE CONCENTRATIONS, AND PITUITARY LEVELS OF LH SUBUNIT MESSENGER-RNAS", Neuroendocrinology, 60(1), 1994, pp. 42-49

Abstract

The functional state of the pituitary-gonadal axis was studied in rats on days 18.5-21.5 of fetal life (f) and on day 4 postpartum by measurements of plasma levels of luteinizing hormone (LH) and testosterone (T). LH was measured using an ultrasensitive immunofluorometric assay. In addition, male fetuses were castrated and exposed to the antiandrogen flutamide (FL; 100 mg/kg BW) or the Leydig cell-specific cytotoxicagent ethylene dimethane sulphonate (EDS, 50 mg/kg BW on 2 days) by injections of the drugs to the mothers. Besides LH and T, pituitary levels of LH subunit mRNAs were measured in these animals. The results allowed the following conclusions: (1) the plasma LH levels in both sexes are low (<0.05 mu g/l, NIH rLH RP-2) on days f18.5 and f19.5; (2) a 4- to 5-fold increase in plasma LH occurs between days f19.5 and f20.5, and a 3- to 4-fold sex difference appears (females > males); (3) theactivation of fetal testicular T production before day f19.5 takes place in the face of very low plasma LH (<0.02 mu g/l), suggesting that some factor(s) other than LH may stimulate the testis at this age; (4)the reciprocal changes of plasma LH and T, and the experiments with castration, EDS and FL demonstrate that testicular feedback regulation of LH secretion is functional from day f19.5 onwards; (5) the parallelchanges of T in male and female fetal plasma suggest that T in femalefetuses comes from male littermates, and (6) the fetal pituitary-testicular axis is less sensitive to hormonal manipulations than that of the postnatal animal, possibly due to interference of maternal and placental hormones with the pituitary-testicular interactions.

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Documento generato il 02/12/20 alle ore 18:22:02