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Titolo:
IN MAN THE MU-OPIATE AGONIST LOPERAMIDE SPECIFICALLY INHIBITS ACTH-SECRETION INDUCED BY THE CHOLECYSTOKININ-LIKE PEPTIDE CERULETIDE
Autore:
AUERNHAMMER CJ; RIEPL RL; SCHOPOHL J; LEHNERT P; MULLER OA; STALLA GK;
Indirizzi:
MAX PLANCK INST PSYCHIAT,INST CLIN,KRAEPELINSTR 10 D-80804 MUNICH GERMANY MAX PLANCK INST PSYCHIAT,INST CLIN D-80804 MUNICH GERMANY UNIV MUNICH,DEPT MED MUNICH GERMANY RED CROSS HOSP,DEPT MED MUNICH GERMANY
Titolo Testata:
Neuroendocrinology
fascicolo: 1, volume: 60, anno: 1994,
pagine: 16 - 22
SICI:
0028-3835(1994)60:1<16:IMTMAL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CORTICOTROPIN-RELEASING HORMONE; GASTRIN-LIKE PEPTIDES; C-FOS EXPRESSION; OPIOID RECEPTORS; BINDING-SITES; RAT; VASOPRESSIN; PITUITARY; OXYTOCIN;
Keywords:
CERULETIDE; LOPERAMIDE; NALOXONE; ADRENOCORTICOTROPIN; HYPOTHALAMUS; ANTERIOR PITUITARY; VAGUS NERVE; OPIATES-AGONISTS; ANTAGONISTS; CORTICOTROPIN; CHOLECYSTOKININ; CHOLECYSTOKININ-ANALOGS; CLINICAL NEUROENDOCRINOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
C.J. Auernhammer et al., "IN MAN THE MU-OPIATE AGONIST LOPERAMIDE SPECIFICALLY INHIBITS ACTH-SECRETION INDUCED BY THE CHOLECYSTOKININ-LIKE PEPTIDE CERULETIDE", Neuroendocrinology, 60(1), 1994, pp. 16-22

Abstract

Ceruletide, a cholecystokinin-8-like peptide, was recently reported to stimulate ACTH secretion in man. The aim of this study was to investigate the effect of the mu-opiate agonist, loperamide, and the opiate antagonist, naloxone, on ceruletide-induced ACTH secretion in man. In 6 normal subjects, basal ACTH and cortisol plasma levels were significantly suppressed 3 h after loperamide administration (16 mg, orally) from 5 +/- 0 to 2 +/- 0 pmol/l and from 356 +/- 44 to 154 +/- 16 nmol/l. After stimulation with 8 ng ceruletide/kg body weight/min over a period of 5 min, the maximum ACTH levels (at 7.5 min) were significantly reduced by loperamide from 26 +/- 7 to 6 +/- 1 pmol/l and the maximum cortisol levels (at 30 min) were significantly reduced from 676 +/- 47to 392 +/- 58 nmol/l. Furthermore, the ACTH peak (Delta = 7.5 min) was significantly blunted by loperamide from 21 +/- 7 to 5 +/- 1 pmol/l and the integrated area under the curve from 0 to 120 min (Delta AUC) of ACTH was significantly reduced from 40 +/- 11 to 14 +/- 4 pmol x 120 min/l. The cortisol peak (Delta = 30 min) and the AUC of cortisol were not significantly diminished. The suppressive effect of loperamide on basal and ceruletide-induced ACTH and cortisol secretion was completely reversed by the administration of 0.8 mg naloxone, 20 min before and during infusion of ceruletide. The administration of naloxone itself had no significant effect on ACTH or cortisol levels. In conclusion, ACTH is released by peripherally administered ceruletide within a short period. The mu-opiate agonist, loperamide, is able to suppress basal and ceruletide-induced ACTH release in man by a naloxone-reversiblemechanism. The ceruletide-stimulated HPA axis in man is influenced bythe opioidergic system.

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Documento generato il 28/11/20 alle ore 04:26:49