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Titolo:
ANTIFILARIAL ACTIVITY OF MACROCYCLIC LACTONES - COMPARATIVE-STUDIES WITH IVERMECTIN, DORAMECTIN, MILBEMYCIN A4 OXIME, AND MOXIDECTIN IN LITOMOSOIDES-CARINII, ACANTHOCHEILONEMA-VITEAE, BRUGIA-MALAYI, AND BRUGIA-PAHANGI INFECTION OF MASTOMYS COUCHA
Autore:
SCHARES G; HOFMANN B; ZAHNER H;
Indirizzi:
UNIV GIESSEN,INST PARASITOL,RUDOLF BUCHHEIM STR 2 D-35392 GIESSEN GERMANY UNIV GIESSEN,INST PARASITOL D-35392 GIESSEN GERMANY
Titolo Testata:
Tropical medicine and parasitology
fascicolo: 2, volume: 45, anno: 1994,
pagine: 97 - 106
SICI:
0177-2392(1994)45:2<97:AAOML->2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIROFILARIA-IMMITIS INFECTION; HAEMONCHUS-CONTORTUS; DIPETALONEMA-VITEAE; EXPERIMENTAL CHEMOTHERAPY; PROPHYLACTIC EFFICACY; RESISTANT STRAIN; NATALENSIS; DOGS; MICROFILARIAE; FILARIASIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
G. Schares et al., "ANTIFILARIAL ACTIVITY OF MACROCYCLIC LACTONES - COMPARATIVE-STUDIES WITH IVERMECTIN, DORAMECTIN, MILBEMYCIN A4 OXIME, AND MOXIDECTIN IN LITOMOSOIDES-CARINII, ACANTHOCHEILONEMA-VITEAE, BRUGIA-MALAYI, AND BRUGIA-PAHANGI INFECTION OF MASTOMYS COUCHA", Tropical medicine and parasitology, 45(2), 1994, pp. 97-106

Abstract

The avermectins ivermectin and doramectin and the milbemycins milbemycin A4 oxime and moxidectin were tested for filaricidal activity in Mastomys coucha infected with Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi, and B. pahangi. Single subcutaneous doses of 0.005-5mg/kg (L. carinii, 0.0005-0.5) mg/kg (A. viteae), 0.5 and 5 mg/kg (B. malayi), and 5 mg/kg (B. pahangi) were injected. Necropsies were performed 42 days after treatment. The avermectins caused a strong and rapid reduction of microfilaraemia in L. carinii and A. viteae infections within a few hours after treatment but showed only moderate efficacies on microfilariae of Brugia spp. The effects of the milbemycin derivatives on L. carinii and A. viteae microfilariae were generally weaker than those of the avermectins. However, moxidectin was comparativelyactive against microfilariae of Brugia spp. Subsequently the parasitaemia levels of L. carinii and A. viteae infected animals remained either almost completely depressed or tended to reincrease in a dose dependent manner whereas there was generally a continuous decrease of microfilaraemia levels in Brugia spp. infected animals. Adulticidal effectswere limited to A. viteae although with neither dose of neither drug > 95 % reductions of adult worm counts were reached. However, pathogenic influences of the drugs were observed on intrauterine embryonic stages of the parasites.

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Documento generato il 29/09/20 alle ore 14:00:40