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Titolo:
SIGNIFICANCE OF IMMUNOHISTOCHEMICAL C-ERBB-2 PRODUCT LOCALIZATION PATTERN FOR PROGNOSIS OF PRIMARY HUMAN BREAST-CANCER
Autore:
ZSCHIESCHE W; SCHONBORN I; MINGUILLON C; SPITZER E;
Indirizzi:
MAX DELBRUCK CTR MOLEC MED,ROBERT ROSSLE STR 10 D-13122 BERLIN GERMANY FREE UNIV BERLIN,UNIV HOSP RUDOLF VIRCHOW,DEPT GYNECOL D-14059 BERLINGERMANY
Titolo Testata:
Cancer letters
fascicolo: 1, volume: 81, anno: 1994,
pagine: 89 - 94
SICI:
0304-3835(1994)81:1<89:SOICPL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HER-2/NEU ONCOGENE EXPRESSION; C-MYC; CELLS; DIFFERENTIATION; OVEREXPRESSION; AMPLIFICATION; PROLIFERATION; CARCINOMA; RECEPTOR; TUMORS;
Keywords:
C-ERBB-2; BREAST CANCER; IMMUNOHISTOCHEMISTRY; PROGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
W. Zschiesche et al., "SIGNIFICANCE OF IMMUNOHISTOCHEMICAL C-ERBB-2 PRODUCT LOCALIZATION PATTERN FOR PROGNOSIS OF PRIMARY HUMAN BREAST-CANCER", Cancer letters, 81(1), 1994, pp. 89-94

Abstract

Concerning immunohistochemistry of the c-erbB-2 receptor in human mammary carcinoma, membranous immunostaining of tumor cells has been generally considered as a potential risk factor for early recurrence, whereas cytoplasmic reactivity has been neglected. An archival study on 463 patients with primary breast cancers demonstrates that cytoplasmic localization of p185 is significantly correlated with high estrogen andprogesterone receptor levels, low histological grade and a low proliferating tumor cell fraction. In accordance with these data, patients bearing mammary carcinomas with cytoplasmic localization of p185 reactivity have a significant better overall survival than those with membranous immunostaining.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:28:38