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Titolo:
ACE-INHIBITION ACCELERATES ENDOTHELIAL REGROWTH IN-VIVO - A POSSIBLE EXPLANATION FOR THE BENEFIT OBSERVED WITH ACE-INHIBITORS FOLLOWING ARTERIAL INJURY
Autore:
VANBELLE E; MEURICE T; TIO FO; CORSEAUX D; DUPUIS B; MCFADDEN EP; LABLANCHE JM; BAUTERS C; BERTRAND ME;
Indirizzi:
UNIV LILLE,DEPT CARDIOL F-59037 LILLE FRANCE UNIV LILLE,DEPT PHARMACOL F-59037 LILLE FRANCE UNIV TEXAS,DEPT PATHOL SAN ANTONIO TX 78284
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 3, volume: 231, anno: 1997,
pagine: 577 - 581
SICI:
0006-291X(1997)231:3<577:AAERI->2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; SMOOTH-MUSCLE; VASCULAR INJURY; CELL-PROLIFERATION; MIGRATION; RESTENOSIS; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
E. Vanbelle et al., "ACE-INHIBITION ACCELERATES ENDOTHELIAL REGROWTH IN-VIVO - A POSSIBLE EXPLANATION FOR THE BENEFIT OBSERVED WITH ACE-INHIBITORS FOLLOWING ARTERIAL INJURY", Biochemical and biophysical research communications, 231(3), 1997, pp. 577-581

Abstract

Recent in vitro studies suggest that angiotensin converting enzyme (ACE) inhibitors stimulate endothelial cell proliferation and migration,The present study was designed to test the hypothesis that an ACE inhibitor may accelerate endothelial regrowth in vivo. Twenty eight New Zealand White rabbits were randomized to receive placebo or the ACE inhibitor perindopril and underwent iliac balloon denudation. Endothelialregrowth, quantified 28 days after injury using Evans blue, was significantly greater in perindopril-treated animals than in controls (131+/-9 mm(2) vs 69+/-8 mm(2); P < .001). These results were confirmed by scanning electron microscopy and by specific immunostaining for endothelial cells. These data provide the first in vivo demonstration that ACE inhibitors accelerate endothelial regrowth after arterial injury, This effect may contribute to the benefit observed with ACE inhibition following arterial injury. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 17:26:21