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Titolo:
THE ESTROGEN-RECEPTOR EXPRESSION IN THE MALE RABBIT URETHRA AND PROSTATE FOLLOWING CASTRATION
Autore:
BODKER A; ANDERSSON KE; BATRA S; JUHL BR; MEYHOFF HH;
Indirizzi:
UNIV COPENHAGEN,GLOSTRUP HOSP,DEPT UROL COPENHAGEN DENMARK UNIV COPENHAGEN,GLOSTRUP HOSP,DEPT PATHOL COPENHAGEN DENMARK CENT HOSP HILLEROD,DEPT SURG HILLEROD DENMARK LUND UNIV,DEPT CLIN PHARMACOL LUND SWEDEN LUND UNIV,DEPT GYNECOL & OBSTET LUND SWEDEN
Titolo Testata:
Scandinavian journal of urology and nephrology
fascicolo: 2, volume: 28, anno: 1994,
pagine: 113 - 118
SICI:
0036-5599(1994)28:2<113:TEEITM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BREAST CANCER; URINARY-TRACT; LOCALIZATION; ESTRADIOL; ASSAY; ANTIBODIES; EPIDIDYMIS; CARCINOMA; INDUCTION; ANDROGEN;
Keywords:
ESTROGEN RECEPTOR; RABBIT URETHRA AND PROSTATE; CASTRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A. Bodker et al., "THE ESTROGEN-RECEPTOR EXPRESSION IN THE MALE RABBIT URETHRA AND PROSTATE FOLLOWING CASTRATION", Scandinavian journal of urology and nephrology, 28(2), 1994, pp. 113-118

Abstract

The influence of castration on estrogen receptor (ER) expression in the male rabbit prostate and urethra, was investigated immunohistochemically and biochemically in 18 mature male, rabbits 14 days after bilateral orchiectomy, and in 15 controls. Immunohistochemical scores of ERwere increased significantly in the prostatic stroma and the urethralsubmucosa (p < 0.05 Mann-Whitney), while the increase in the urothelium was not significant. Biochemically, the ER content was 87.4 +/- 42.6 f mol/ mg protein in the normal prostate, and 190.0 +/- 28.0 mol/mg protein following castration. The corresponding values for the posterior urethra were 228.3 +/- 43.2 f mol/mg protein and 354.9 +/- 60.1 f mol/mg protein. In both cases the increase was not significant. We conclude, that ERs in the prostate and the urethra of the male rabbit can be modified by hormonal manipulation. ERs may therefore be functionally active and not rudimentary.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 15:02:34