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Titolo:
DIFFERENTIAL INTEGRIN EXPRESSION FACILITATES ISOLATION OF HUMAN FETALPANCREATIC EPITHELIAL-CELLS
Autore:
LEVINE F; BEATTIE GM; HAYEK A;
Indirizzi:
UNIV CALIF SAN DIEGO,SCH MED,CTR MOLEC GENET,DEPT PEDIAT LA JOLLA CA 92093 WHITTIER INST DIABET & ENDOCRINOL,LUCY THORNE WHITTIER CHILDRENS CTR LA JOLLA CA 92037
Titolo Testata:
Cell transplantation
fascicolo: 4, volume: 3, anno: 1994,
pagine: 307 - 313
SICI:
0963-6897(1994)3:4<307:DIEFIO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLET CELLS; YERSINIA-PSEUDOTUBERCULOSIS; ADHESION MOLECULE; MAMMALIAN-CELLS; INVASIN PROTEIN; NUDE-MICE; VIRUS; TRANSPLANTATION; LOCALIZATION; MODULATION;
Keywords:
BETA-1 INTEGRIN; HUMAN FETAL PANCREAS; INVASIN; CELL ISOLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
F. Levine et al., "DIFFERENTIAL INTEGRIN EXPRESSION FACILITATES ISOLATION OF HUMAN FETALPANCREATIC EPITHELIAL-CELLS", Cell transplantation, 3(4), 1994, pp. 307-313

Abstract

We have studied the expression of the beta 1 family of integrins in fetal and adult human pancreas. Immunohistochemical staining with a monoclonal anti-beta 1 antibody revealed that the epithelial cells of thehuman fetal pancreas express high amounts of beta 1 integrin, while the pancreatic stromal cells express substantially lower amounts. Islets of Langerhans from human adult pancreas also expressed high amounts of beta 1 integrin. Taking advantage of the extremely high affinity binding between the invasin protein of Yersinia pseudotuberculosis and many beta 1 integrins, we have been able to isolate highly enriched populations of fetal pancreatic epithelial cells. Epithelial-enriched cell populations retain the ability to differentiate into mature endocrine cells following transplantation into nude mice.

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Documento generato il 05/07/20 alle ore 09:31:51