Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HUMAN-IMMUNOGLOBULIN V-H-SEGMENT AND D-SEGMENT ON CHROMOSOME-15Q11.2 AND CHROMOSOME-16P11.2
Autore:
TOMLINSON IM; COOK GP; CARTER NP; ELASWARAPU R; SMITH S; WALTER G; BULUWELA L; RABBITTS TH; WINTER G;
Indirizzi:
MRC,MOLEC BIOL LAB,HILLS RD CAMBRIDGE CB2 2QH ENGLAND MRC,MOLEC BIOL LAB CAMBRIDGE CB2 2QH ENGLAND MRC,CTR PROT ENGN CAMBRIDGE CB2 2QH ENGLAND UNIV CAMBRIDGE,DEPT PATHOL CAMBRIDGE CB2 1QP ENGLAND MRC,CLIN RES CTR HARROW HA1 3UJ MIDDX ENGLAND
Titolo Testata:
Human molecular genetics
fascicolo: 6, volume: 3, anno: 1994,
pagine: 853 - 860
SICI:
0964-6906(1994)3:6<853:HVADOC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHAIN VARIABLE REGION; VH4 GENE FAMILY; HEAVY-CHAIN; INSITU HYBRIDIZATION; PRADER-WILLI; LOCUS; ORGANIZATION; IDENTIFICATION; REPERTOIRE; SEQUENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
I.M. Tomlinson et al., "HUMAN-IMMUNOGLOBULIN V-H-SEGMENT AND D-SEGMENT ON CHROMOSOME-15Q11.2 AND CHROMOSOME-16P11.2", Human molecular genetics, 3(6), 1994, pp. 853-860

Abstract

In addition to the major human immunoglobulin heavy-chain locus on chromosome 14q32.3, V-H and D segments are known to be present on chromosomes 15 and 16. We have now amplified and sequenced 24 such V-H segments from somatic cell hybrids and have assigned them to 15q11.2 and 16p11.2 using cosmid and yeast artificial chromosome clones. In addition, we have located a cluster of D segments on 15q.11.2, previously thought to be located on 14q32.3. We propose that the segments on chromosome 16 arose by an interchromosomal duplication and identify the corresponding region on chromosome 14. Taken together with the completion ofa map of the human V-H locus on 14q32.3, the total number of V-H segments now identified is 117. We can now account for most, if not all human germ-line V-H segments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:22:21