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Titolo:
EARLY CHANGES IN LUNG-FUNCTION AND RESPONSE TO SURFACTANT REPLACEMENTTHERAPY
Autore:
GIBSON AT; PRIMHAK RA;
Indirizzi:
UNIV SHEFFIELD,JESSOP HOSP WOMEN,DEPT PAEDIAT SHEFFIELD S3 7RE ENGLAND
Titolo Testata:
European journal of pediatrics
fascicolo: 7, volume: 153, anno: 1994,
pagine: 495 - 500
SICI:
0340-6199(1994)153:7<495:ECILAR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; ARTIFICIAL SURFACTANT; SYNTHETIC SURFACTANT; EXOGENOUS SURFACTANT; PULMONARY MECHANICS; PRETERM INFANTS; NEWBORN-INFANTS; PREMATURE LAMBS; RABBIT LUNGS; SYSTEM;
Keywords:
SURFACTANT; PRETERM INFANT; DYNAMIC COMPLIANCE; RESPIRATORY DISTRESS SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A.T. Gibson e R.A. Primhak, "EARLY CHANGES IN LUNG-FUNCTION AND RESPONSE TO SURFACTANT REPLACEMENTTHERAPY", European journal of pediatrics, 153(7), 1994, pp. 495-500

Abstract

Dynamic respiratory system compliance (Cdyn) was measured in 44 preterm babies before, immediately after, and for 96 h following administration of artificial surfactant (Exosurf). There was no significant change in Cdyn for the whole group over the entire study period. Subdivision into three groups on the basis of Cdyn prior to surfactant revealeda significant and sustained deterioration in lung function in those babies with the highest starting compliance and a significant and sustained improvement in those with the lowest compliance. Inspired oxygen and alveolar/arterial oxygen gradient also exhibited significant differences with least improvement in the babies with the best initial lungfunction and most improvement in the babies with worst initial lung function. Despite clear initial differences in clinical status, neitherlong-term oxygen requirements nor the incidence of chronic lung disease differed significantly between the three groups. We conclude that the response of an individual baby to the administration of surfactant is, in part, determined by the lung function before surfactant is administered. Babies with higher initial lung compliance are more likely to deteriorate after administration and caution should be used before selection of such babies for surfactant treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:21:37