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Titolo:
ORAL DELAYED-RELEASE SYSTEM FOR COLONIC SPECIFIC DELIVERY
Autore:
GAZZANIGA A; IAMARTINO P; MAFFIONE G; SANGALLI ME;
Indirizzi:
UNIV MILAN,IST CHIM FARMACEUT,VIALE ABRUZZI 42 I-20131 MILAN ITALY BOEHRINGER INGELHEIM ITALIA I-20139 MILAN ITALY UNIV PAVIA,DIPARTIMENTO CHIM FARMACEUT PAVIA ITALY
Titolo Testata:
International journal of pharmaceutics
fascicolo: 1, volume: 108, anno: 1994,
pagine: 77 - 83
SICI:
0378-5173(1994)108:1<77:ODSFCS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUGS; BACTERIA; TRANSIT; INSULIN; MATRIX;
Keywords:
COLONIC SPECIFIC DELIVERY; ORAL TIME-BASED SYSTEM; DELAYED RELEASE; FILM COATING; HIGH-VISCOSITY HPMC; SMALL INTESTINE TRANSIT TIME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
A. Gazzaniga et al., "ORAL DELAYED-RELEASE SYSTEM FOR COLONIC SPECIFIC DELIVERY", International journal of pharmaceutics, 108(1), 1994, pp. 77-83

Abstract

The paper describes a novel oral time-based drug release system for colonic specific delivery. The system, designed to exploit the relatively constant small intestine transit time of dosage forms, consists of drug-containing cores coated with three polymeric layers. The outer layer dissolves at pH > 5, then the intermediate swellable layer, made of high-viscosity HPMC, interacts slowly with aqueous fluids, thus providing the delay phase. The inner film is made of an enteric material. The system provides the expected delayed release pattern, as also indicated by the preliminary in vivo experiments on rats.

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Documento generato il 14/07/20 alle ore 06:07:32