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Titolo:
D-RIBOSE AND DEOXY-D-RIBOSE INDUCE APOPTOSIS IN HUMAN QUIESCENT PERIPHERAL-BLOOD MONONUCLEAR-CELLS
Autore:
BARBIERI D; GRASSILLI E; MONTI D; SALVIOLI S; FRANCESCHINI MG; FRANCHINI A; BELLESIA E; SALOMONI P; NEGRO P; CAPRI M; TROIANO L; COSSARIZZA A; FRANCESCHI C;
Indirizzi:
DIPARTIMENTO SCI BIOMED,SEZ PATOL GEN,VIA CAMPI 287 I-41100 MODENA ITALY DIPARTIMENTO SCI BIOMED,SEZ PATOL GEN I-41100 MODENA ITALY DIPARTIMENTO BIOL ANIM I-41100 MODENA ITALY
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 3, volume: 201, anno: 1994,
pagine: 1109 - 1116
SICI:
0006-291X(1994)201:3<1109:DADIAI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXAMETHASONE-INDUCED APOPTOSIS; A-INDUCED PROLIFERATION; HUMAN-LYMPHOCYTES; DEATH APOPTOSIS; RAT THYMOCYTES; INHIBITION; DEFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
D. Barbieri et al., "D-RIBOSE AND DEOXY-D-RIBOSE INDUCE APOPTOSIS IN HUMAN QUIESCENT PERIPHERAL-BLOOD MONONUCLEAR-CELLS", Biochemical and biophysical research communications, 201(3), 1994, pp. 1109-1116

Abstract

In previous papers we reported that D(-)-ribose and 2-deoxy-D-ribose,which rank at the top among reducing sugars, kill a variety of human and animal cells and cell lines [1, 2]. Here we demonstrate that thesetwo sugars induce apoptosis in human quiescent peripheral blood mononuclear cells which are relatively insensitive to apoptosis. Apoptosis was assessed by morphological changes, DNA fragmentation by agarose gel electrophoresis and the appearance of an hypodiploid peak by flow cytometry. 2-deoxy-D-ribose was more potent than D(-)-ribose and apoptosis was evident from 48 hours of culture onwards. 2-deoxy-D-ribose-induced apoptosis was inibited by N-acetyl-L-cysteine, suggesting that glutathione metabolism and/or oxidative stress are involved in this type of apoptosis. Thus, D(-)-ribose and 2-deoxy-D-ribose can be useful tools to study the cellular and molecular events of apoptosis in human quiescent lymphocytes. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:33:04