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Titolo:
CHROMOSOME-ABERRATIONS IN LYMPHOCYTES FROM WOMEN IRRADIATED FOR BENIGN AND MALIGNANT GYNECOLOGICAL DISEASE
Autore:
KLEINERMAN RA; LITTLEFIELD LG; TARONE RE; SAYER AM; COOKFAIR DL; WACTAWSKIWENDE J; INSKIP PD; BLOCK AMW; RAMESH KH; BOICE JD;
Indirizzi:
NCI,RADIAT EPIDEMIOL BRANCH,EPN 408 BETHESDA MD 20892 OAK RIDGE INST SCI & EDUC,DIV MED SCI OAK RIDGE TN 37831 NCI,BIOSTAT BRANCH BETHESDA MD 20892 SUNY COLL BUFFALO,DEPT NEUROL BUFFALO NY 14222 SUNY BUFFALO,DEPT SOCIAL & PREVENT MED BUFFALO NY 14214 SUNY BUFFALO,SCH MED & BIOMED SCI,DEPT GYNECOL & OBSTET NEW YORK NY 14219 SUNY BUFFALO,SCH MED & BIOMED SCI,DEPT SOCIAL & PREVENT MED NEW YORK NY 14219 ROSWELL PK CANC INST,CLIN CYTOGENET LAB BUFFALO NY 14263
Titolo Testata:
Radiation research
fascicolo: 1, volume: 139, anno: 1994,
pagine: 40 - 46
SICI:
0033-7587(1994)139:1<40:CILFWI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD LYMPHOCYTES; ACTIVE BONE-MARROW; CONTROL POPULATION; X-IRRADIATION; RADIATION; CANCER; RADIOTHERAPY; FREQUENCY; LEUKEMIA; CERVIX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Kleinerman et al., "CHROMOSOME-ABERRATIONS IN LYMPHOCYTES FROM WOMEN IRRADIATED FOR BENIGN AND MALIGNANT GYNECOLOGICAL DISEASE", Radiation research, 139(1), 1994, pp. 40-46

Abstract

Excess leukemias have occurred after partial-body radiotherapy for cervical cancer and benign gynecological disease (BGD). However, the level of risk is nearly the same in both groups, about twofold, despite atenfold difference in average dose to active bone marrow (8 Gy vs 0.7Gy, respectively). High-dose cell killing has been postulated as one explanation for this apparent inconsistency. To examine whether chromosome aberration rates observed in lymphocytes many years after exposure might serve as population markers of cancer risk, blood samples weretaken from 60 women treated for BGD (34 with radiation) and cytogenetic data compared with previous results from 96 women irradiated for cervical cancer. Remarkably, the rate of stable aberrations, which reflects nonlethal damage in surviving stem cells, was only slightly higheramong the cancer patients. Thus the lower-dose regimens to treat benign disorders resulted in much higher aberration yields per unit dose than those for cervical cancer. Assuming that the fraction of cytogenetically aberrant stem cells that survive radiotherapy contributes to the leukemogenic process, these data are then consistent with the epidemiological observations of comparable overall leukemia risks seen in these two irradiated populations. Accordingly, for patient populations given partial-body radiotherapy, stable aberrations at a long time after exposure appear to serve as biomarkers of effective risk rather thanas biomarkers of radiation dose received.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:28:47