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Titolo:
DOWN-REGULATION OF HUMAN TUMOR NECROSIS FACTOR-BETA GENE-EXPRESSION BY CELLS WITH SUPPRESSIVE ACTIVITY
Autore:
AFRAMIAN D; KATZENELLENBOGEN M; ARAD G; OSMAN F; SAYAR D; KETZINEL M; DEUTSCH E; KAEMPFER R;
Indirizzi:
HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MOL VIROL IL-91120 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MOL VIROL IL-91120 JERUSALEM ISRAEL BIKUR CHOLIM HOSP,DEPT OTORHINOLARYNGOL JERUSALEM ISRAEL
Titolo Testata:
Immunology letters
fascicolo: 2-3, volume: 54, anno: 1996,
pagine: 171 - 176
SICI:
0165-2478(1996)54:2-3<171:DOHTNF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LYMPHOCYTES-T; INTERFERON-GAMMA; HUMAN INTERLEUKIN-2; FACTOR-ALPHA; LYMPHOTOXIN; CYCLOPHOSPHAMIDE; INHIBITION; INVITRO; 4-HYDROPEROXYCYCLOPHOSPHAMIDE; SUBPOPULATIONS;
Keywords:
CD8 CELLS; CD11B CELLS; HUMAN TUMOR NECROSIS FACTOR-BETA GENE REGULATION; IMMUNOSUPPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
D. Aframian et al., "DOWN-REGULATION OF HUMAN TUMOR NECROSIS FACTOR-BETA GENE-EXPRESSION BY CELLS WITH SUPPRESSIVE ACTIVITY", Immunology letters, 54(2-3), 1996, pp. 171-176

Abstract

Human TNF-beta (lymphotoxin) gene expression is down-regulated by immunosuppression. Induction of TNF-beta mRNA in lymphoid cells is greatly enhanced by gamma-irradiation, cyclophosphamide and cimetidine, agents that each inhibit activation of suppressive cells. The level of TNF-beta mRNA expressed in response to stimulation, whether by mitogen orantigen, is reduced strongly by concomitant activation of suppressivecell subsets. Removal of CD8 or CD11b cells leads to a pronounced superinduction of TNF-beta mRNA in the depleted cell population. Induction of TNF-beta mRNA precedes appearance of suppressive cell activity, allowing for temporary expression. The TNF-beta gene is as sensitive asIFN-gamma and IL-2 genes to suppression. Hence, three genes characteristically expressed in Th1 cells, encoding IL-2, IFN-gamma, and TNF-beta, are similarly regulated by cell-mediated suppression. Actual levels of TNF-beta during an immune response are determined by the balance between activities of expressing and suppressing cell subsets, both transiently manifested. (C) 1996 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 02:54:28