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Titolo:
CHANGED EXCRETION OF URINARY PROTEINS AND ENZYMES BY CHRONIC EXPOSURETO LEAD
Autore:
PERGANDE M; JUNG K; PRECHT S; FELS LM; HERBORT C; STOLTE H;
Indirizzi:
HUMBOLDT UNIV BERLIN,UNIV HOSP CHARITE,DEPT UROL,RES DIV,SCHUMANNSTR 20-21 D-10098 BERLIN GERMANY HUMBOLDT UNIV BERLIN,UNIV HOSP CHARITE,DEPT UROL,RES DIV,SCHUMANNSTR 20-21 D-10098 BERLIN GERMANY HANNOVER MED SCH,DEPT INTERNAL MED,DIV NEPHROL W-3000 HANNOVER 61 GERMANY
Titolo Testata:
Nephrology, dialysis, transplantation
fascicolo: 6, volume: 9, anno: 1994,
pagine: 613 - 618
SICI:
0931-0509(1994)9:6<613:CEOUPA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEPHROTOXICITY; MECHANISMS; NEPHROPATHIES; DYSFUNCTION; MARKERS; CADMIUM;
Keywords:
HIGH-MOLECULAR-WEIGHT PROTEIN; LEAD NEPHROPATHY; LOW-MOLECULAR-WEIGHT PROTEIN; OCCUPATION; TUBULE; URINARY ENZYMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Pergande et al., "CHANGED EXCRETION OF URINARY PROTEINS AND ENZYMES BY CHRONIC EXPOSURETO LEAD", Nephrology, dialysis, transplantation, 9(6), 1994, pp. 613-618

Abstract

Fifteen various serum and urine parameters were evaluated as indicators of renal alterations induced by lead in 82 male workers of a battery plant chronically exposed to lead (median of blood lead concentration: 2.03 mumol/l). The control group comprised 44 non-exposed healthy volunteers (0.34 mumol/l). High-molecular-mass proteins (transferrin, immunoglobulin G (IgG), (albumin)) were determined in urine as markers of glomerular integrity; low-molecular-weight proteins and parenchymalenzymes (alpha1-microglobulin, beta2-microglobulin, retinol-binding protein, lysozyme, ribonuclease, N-acetyl-beta-D-glucosaminidase (NAG),alanine aminopeptidase (AAP), alkaline phosphatase (AP), gamma-glutamyltransferase (GGT)) as indicators of changes in the proximal tubule; Tamm-Horsfall glycoprotein and kallikrein as markers of the distal tubule. There was a positive correlation between tubular indicators and blood lead concentration as well as the erythrocyte protoporphyrin (EPP). About 30% of the lead-exposed workers showed an increased excretionof alpha1-microglobulin, NAG, ribonuclease, and/or Tamm-Horsfall protein, whereas the glomerular indicators remained unchanged. The combined determination of NAG and alpha1-microglobulin in urine could be helpful in the early detection of lead-induced changes in the nephron.

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Documento generato il 15/08/20 alle ore 18:36:55