Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
VASOACTIVE INTESTINAL POLYPEPTIDE MICROINJECTIONS INTO THE ORAL PONTINE TEGMENTUM ENHANCE RAPID EYE-MOVEMENT SLEEP IN THE RAT
Autore:
BOURGIN P; LEBRAND C; ESCOURROU P; GAULTIER C; FRANC B; HAMON M; ADRIEN J;
Indirizzi:
CHU PITIE SALPETRIERE,INSERM U288 PARIS FRANCE CHU KREMLIN BICETRE,DEPT PHYSIOL LE KREMLIN BICETR FRANCE
Titolo Testata:
Neuroscience
fascicolo: 2, volume: 77, anno: 1997,
pagine: 351 - 360
SICI:
0306-4522(1997)77:2<351:VIPMIT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; SUPERIOR CERVICAL-GANGLION; PROLACTIN MESSENGER-RNA; CEREBROSPINAL-FLUID CSF; REM-SLEEP; RETICULAR-FORMATION; PEPTIDE VIP; CHOLINE-ACETYLTRANSFERASE; HYPNOGENIC PROPERTIES; PERIBRACHIAL NUCLEUS;
Keywords:
SLEEP-WAKEFULNESS CYCLE; NUCLEUS RETICULARIS PONTIS ORALIS; VASOACTIVE INTESTINAL PEPTIDE; LONG-TERM INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
P. Bourgin et al., "VASOACTIVE INTESTINAL POLYPEPTIDE MICROINJECTIONS INTO THE ORAL PONTINE TEGMENTUM ENHANCE RAPID EYE-MOVEMENT SLEEP IN THE RAT", Neuroscience, 77(2), 1997, pp. 351-360

Abstract

Rapid eye movement sleep can be elicited in the rat by microinjectionof the cholinergic agonist carbachol into the oral pontine reticular nucleus. Intracerebroventricular administration, during the light period, of vasoactive intestinal peptide enhances rapid eye movement sleepin several species. Since this peptide is co-localized with acetylcholine in many neurons in the central nervous system, it was assumed that the oral pontine tegmentum could also be one target for vasoactive intestinal peptide to induce rapid eye movement sleep. This hypothesis was tested by recording the sleep-wakefulness cycle in freely-moving rats injected with vasoactive intestinal peptide or its fragments (1-12and 10-28) directly into the oral pontine reticular nucleus. When administered into the posterior part of this nucleus, vasoactive intestinal peptide at 1 and 10 ng (in 0.1 mu l of saline), but not its fragments, induced a 2-fold enhancement of rapid eye movement sleep during 4 h, at the expense of wakefulness. At the dose of 10 ng, a significant increase in rapid eye movement sleep persisted for up to Sh. Moreover,when the peptide was injected into the centre of the positive zone, rapid eye movement sleep was enhanced during three to eight consecutivedays. These data provide the first evidence that rapid eye movement sleep can be elicited at both short- and long-term by a single intracerebral microinjection of vasoactive intestinal peptide. Peptidergic mechanisms, possibly in association with cholinergic mechanisms, within the caudal part of the oral pontine reticular nucleus may play a critical role in the long-term regulation of rapid eye movement sleep in rats. (C) 1997 IBRO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:40:17