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Titolo:
HEPATITIS DUE TO DROXICAM - DESCRIPTION O F 3 NEW CASES AND LITERATURE-REVIEW
Autore:
GONZALEZ MG; SANROMAN AL; HERRERO C; LEDO L; MORENO A; GONZALEZ C; MOREIRA V;
Indirizzi:
HOSP RAMON & CAJAL,SERV GASTROENTEROL,CARRETERA COLMENAR VIEJO KM 9-400 E-28034 MADRID SPAIN
Titolo Testata:
Revista Clinica Espanola
fascicolo: 3, volume: 194, anno: 1994,
pagine: 170 - 172
SICI:
0014-2565(1994)194:3<170:HDTD-D>2.0.ZU;2-J
Fonte:
ISI
Lingua:
SPA
Keywords:
DROXICAM; TOXIC HEPATITIS; HYPERLIPEMIA AS A SIDE EFFECT OF DROXICAM;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
M.G. Gonzalez et al., "HEPATITIS DUE TO DROXICAM - DESCRIPTION O F 3 NEW CASES AND LITERATURE-REVIEW", Revista Clinica Espanola, 194(3), 1994, pp. 170-172

Abstract

Three new cases of cholestatic hepatitis caused by droxicam are described, along with a revision of the other eight cases published to date. Itching, asthenia, and jaundice were the most common symptoms. Average age was 62.8 years (range: 45-82 years), and the median time of exposition was 22.7 days (range: 5-50 days). Biochemistry of the liver showed primarily cholestasis and in 4/11 cases hypereosinophilia. Two patients presented elevated levels of cholesterol and triglycerides which disappeared within the month. Clinical manifestations persisted in one patient for eight weeks after the cessation of treatment. The threepatients presented in the present series presented alteration in the biochemistry of the liver two months after initiation. Liver biopsy inthree patients showed centrozonal cholestasis associated with portal inflammatory activity and presence of granulomas consistent with toxichepatitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 11:23:20