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Titolo:
THE ENDOTHELIN ET(B) RECEPTOR AGONIST, IRL-1620, CAUSES VASODILATATION AND INHIBITS EX-VIVO PLATELET-AGGREGATION IN THE ANESTHETIZED RABBIT
Autore:
MCMURDO L; THIEMERMANN C; VANE JR;
Indirizzi:
UNIV LONDON ST BARTHOLOMEWS HOSP & MED COLL,WILLIAM HARVEY RES INST,CHARTERHOUSE SQ LONDON EC1M 6BQ ENGLAND UNIV LONDON ST BARTHOLOMEWS HOSP & MED COLL,WILLIAM HARVEY RES INST LONDON EC1M 6BQ ENGLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 259, anno: 1994,
pagine: 51 - 55
SICI:
0014-2999(1994)259:1<51:TEERAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIZED RAT; PROSTACYCLIN RELEASE; ETB-RECEPTOR; IRL-1620; )ALA1,3,11,15>ENDOTHELIN-1; ET(B)-RECEPTOR; HETEROGENEITY; CIRCULATION; ACTIVATION; MEDIATION;
Keywords:
ENDOTHELIN; ENDOTHELIN ET(B) RECEPTOR; ENDOTHELIN ET(A) RECEPTOR; PROSTACYCLIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
L. Mcmurdo et al., "THE ENDOTHELIN ET(B) RECEPTOR AGONIST, IRL-1620, CAUSES VASODILATATION AND INHIBITS EX-VIVO PLATELET-AGGREGATION IN THE ANESTHETIZED RABBIT", European journal of pharmacology, 259(1), 1994, pp. 51-55

Abstract

The ET(B) receptor agonist, IRL 1620 injected into the left ventricle, induced a biphasic (transient fall followed by a secondary fall lasting 5 min) depressor response in the anaesthetised rabbit. This was followed by a rise in systemic blood pressure which returned to control levels within 30 min. In addition, IRL 1620 caused a strong, transientinhibition of ADP-induced platelet aggregation ex vivo. The selectiveET(A) receptor antagonist, FR 139317 had no effect on either the haemodynamic or anti-aggregatory effects of IRL 1620. Indomethacin which had no effect on the initial transient depressor response induced by IRL 1620, abolished the secondary fall revealing a sustained presser response. Indomethacin also prevented the IRL 1620-induced inhibition of platelet aggregation ex vivo. Thus, IRL 1620 is a selective ET(B) receptor agonist in the anaesthetised rabbit, causing vasodilatation, vasoconstriction and inhibition of ex vivo platelet aggregation. The inhibition of platelet aggregation by IRL 1620 is due to an ET(B) receptor-mediated release of prostacyclin into the circulation, for it is inhibited by indomethacin, but not by FR 139317.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:47:54