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Titolo:
EFFECTS OF FENOLDOPAM ON INTRACRANIAL-PRESSURE AND HEMODYNAMIC VARIABLES AT NORMAL AND ELEVATED INTRACRANIAL-PRESSURE IN ANESTHETIZED PIGS
Autore:
HENNES HJ; JANTZEN JPAH;
Indirizzi:
JOHANNES GUTENBERG UNIV,SCH MED,DEPT ANESTHESIOL,LANGENBECKSTR 1 D-55131 MAINZ GERMANY
Titolo Testata:
Journal of neurosurgical anesthesiology
fascicolo: 3, volume: 6, anno: 1994,
pagine: 175 - 181
SICI:
0898-4921(1994)6:3<175:EOFOIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL BLOOD-FLOW; INTRAOCULAR-PRESSURE; INTRAVENOUS FENOLDOPAM; HYPERTENSIVE PATIENTS; NITROPRUSSIDE; HYPOTENSION; AGONIST; ANESTHESIA; RECEPTORS; DOGS;
Keywords:
HYPERTENSION; FENOLDOPAM; ANGIOTENSIN-II; INTRAOCULAR PRESSURE; INTRACRANIAL PRESSURE; PIG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Hennes e J.P.A.H. Jantzen, "EFFECTS OF FENOLDOPAM ON INTRACRANIAL-PRESSURE AND HEMODYNAMIC VARIABLES AT NORMAL AND ELEVATED INTRACRANIAL-PRESSURE IN ANESTHETIZED PIGS", Journal of neurosurgical anesthesiology, 6(3), 1994, pp. 175-181

Abstract

Fenoldopam (FE), a dopamine DA1-receptor agonist, has been introducedfor treatment of arterial hypertension and heart failure and for preservation of renal function. Vasodilators are generally assumed to affect all vascular beds including the cerebral circulation. We have evaluated effects of FE-induced (4 mug . kg-1 . min-1) arterial hypotensionon intracranial pressure (ICP) and intraocular pressure (IOP) under conditions of normal and increased intracranial elastance. ICP and IOP responses to hypertension were tested by infusion of angiotensin II (15 mug . kg-1 . min-1), and the response to hypercapnia was tested by elimination and reintegration of soda lime canisters in the breathing circuit. Intracranial elastance was increased by infusing mock cerebrospinal fluid (CSF) into the lateral ventricle (20 +/- 3 ml . h-1). Arterial hypotension induced with FE did not increase ICP. With increased intracranial elastance, the infusion rate of mock CSF had to be reduced while administering, FE to avoid a rise in ICP (p < 0.05 compared with preinfusion value); this indicates a shift on the volume-pressure curve to the right. There were no indicators that cerebral autoregulation or CO2 reactivity of the cerebral vasculature were affected by FE in this anesthetized porcine model, as speculated from analysis of the time course of DELTA ICP. There are, however, indicators of increased intracranial elastance, most likely caused by vasodilation. Caution should hence be exercised when FE is administered to patients with increased intracranial elastance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:46:23