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Titolo:
ANTI-IL-4 TREATMENT OF SCHISTOSOMA-MANSONI-INFECTED MICE INHIBITS DEVELOPMENT OF T-CELLS AND NON-B, NON-T CELLS EXPRESSING TH2 CYTOKINES WHILE DECREASING EGG-INDUCED HEPATIC-FIBROSIS
Autore:
CHEEVER AW; WILLIAMS ME; WYNN TA; FINKELMAN FD; SEDER RA; COX TM; HIENY S; CASPAR P; SHER A;
Indirizzi:
NIAID,PARASIT DIS LAB,BLDG 4,RM 126 BETHESDA MD 20892 NIAID,IMMUNOL LAB BETHESDA MD 20892 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT MED BETHESDA MD 20892
Titolo Testata:
The Journal of immunology
fascicolo: 2, volume: 153, anno: 1994,
pagine: 753 - 759
SICI:
0022-1767(1994)153:2<753:ATOSMI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE SCHISTOSOMIASIS; GRANULOMA-FORMATION; CD4+ LYMPHOCYTES; DOWN-REGULATION; GOAT ANTIBODY; MOUSE IGD; IL-4; INTERLEUKIN-4; EOSINOPHILIA; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A.W. Cheever et al., "ANTI-IL-4 TREATMENT OF SCHISTOSOMA-MANSONI-INFECTED MICE INHIBITS DEVELOPMENT OF T-CELLS AND NON-B, NON-T CELLS EXPRESSING TH2 CYTOKINES WHILE DECREASING EGG-INDUCED HEPATIC-FIBROSIS", The Journal of immunology, 153(2), 1994, pp. 753-759

Abstract

Increasing evidence suggests that schistosome egg granulomas are primarily Th2 cellular reactions. Mice infected with Schistosoma mansoni were treated with a neutralizing mAb against IL-4 to evaluate the role of this cytokine in the generation of parasite egg-induced cell-mediated responses and hepatic pathology. Animals treated with anti-IL-4 before egg deposition showed decreased IL-4, IL-5, and IL-10 production in response to in vitro antigenic stimulations and decreased IL-5 and IL-13 mRNA levels in the liver. As observed previously, non-B, non-T cells were a major source of IL-4 in infected mice treated with control mAb, and the diminished IL-4 response in anti-IL-4-treated animals wasshown to be caused at least in part by a reduction in the number of these cells, as well as by decreased secretion of IL-4 per cell. In contrast, production of the Th1 cytokines IL-2 and IFN-gamma was elevatedin anti-IL-4-treated infected mice in vitro, and the corresponding mRNAs in the liver were increased. Anti-IL-4 treatment did not consistently reduce the size of hepatic granulomas around S. mansoni eggs, but markedly inhibited granuloma formation in the lungs of the same animals after i.v. egg injection. Nevertheless, anti-IL-4-treated infected mice showed consistent and marked reductions in hepatic collagen deposition. These findings indicate that IL-4 plays a major role in the development of the Th2 response in S. mansoni-infected mice and contributes to the pathogenesis of hepatic fibrosis.

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Documento generato il 28/11/20 alle ore 00:28:34