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Titolo:
NMDA ANTAGONISTS POTENTIATE SCOPOLAMINE-INDUCED AMNESIC EFFECT
Autore:
LI HB; MATSUMOTO K; TOHDA M; YAMAMOTO M; WATANABE H;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,DIV PHARMACOL,2630 SUGITANI TOYAMA 93001 JAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,DIV PHARMACOL TOYAMA 93001 JAPAN YAMANOUCHI PHARMACEUT CO LTD,CLIN PHARMACOL RES LAB TOKYO 174 JAPAN
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 83, anno: 1997,
pagine: 225 - 228
SICI:
0166-4328(1997)83:1-2<225:NAPSAE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; METHYL-D-ASPARTATE; MAZE PERFORMANCE; HIPPOCAMPUS; MEMORY; RATS; MICRODIALYSIS; MK-801;
Keywords:
N-METHYL-D-ASPARTATE (NMDA) ANTAGONIST; MK-801; CGS-19755; SCOPOLAMINE-INDUCED AMNESIA; RADIAL MAZE PERFORMANCE; LEARNING IMPAIRMENT; MEMORY IMPAIRMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
H.B. Li et al., "NMDA ANTAGONISTS POTENTIATE SCOPOLAMINE-INDUCED AMNESIC EFFECT", Behavioural brain research, 83(1-2), 1997, pp. 225-228

Abstract

The effects of N-methyl-D-aspartate NMDA receptor antagonists on scopolamine-induced amnesia and on delay-interposed short-term memory performance were investigated using an 8-arm radial maze in rats. Scopolamine, a muscarinic antagonist, deteriorated the radial maze performance, while MK-801, an NMDA receptor channel blocker and CGS-19755, a competitive NMDA receptor antagonist, showed no obstruction to the spatialcognition in the non-delayed maze task. MK-801 (0.01-0.03 mg/kg, i.v.) and CGS-19755 (1-10 mg/kg, i.v.) significantly augmented scopolamine-induced deficit in the non-delayed maze task and impaired the short-term memory in the 5-min delay-interposed task. These results suggest that NMDA antagonists have a negative action on short-term memory and that the interaction between the NMDA and the central muscarinic systemplays a role in modulating the cognitive function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 01:58:33