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Titolo:
DEHYDROEPIANDROSTERONE-SULFATE ATTENUATES DIZOCILPINE-INDUCED LEARNING IMPAIRMENT IN MICE VIA SIGMA(1)-RECEPTORS
Autore:
MAURICE T; JUNIEN JL; PRIVAT A;
Indirizzi:
ECOLE NATL SUPER CHIM MONTPELLIER,INSERM U336,8 RUE ECOLE NORMALE F-34053 MONTPELLIER 1 FRANCE MCGILL UNIV,DOUGLAS HOSP,RES CTR MONTREAL PQ H4H 1R3 CANADA
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 83, anno: 1997,
pagine: 159 - 164
SICI:
0166-4328(1997)83:1-2<159:DADL>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; INDUCED NEURONAL ACTIVATION; PREGNENOLONE-SULFATE; SIGMA-RECEPTORS; STEROID BINDING; MEMORY; HIPPOCAMPUS; ANTAGONIST; RESPONSES; INCREASES;
Keywords:
NEUROSTEROID; DEHYDROEPIANDROSTERONE SULFATE (DHEAS); DIZOCILPINE; N-METHYL-D-ASPARTATE RECEPTOR; SIGMA TYPE 1 (SIGMA(1)) RECEPTOR; LEARNING AND MEMORY; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T. Maurice et al., "DEHYDROEPIANDROSTERONE-SULFATE ATTENUATES DIZOCILPINE-INDUCED LEARNING IMPAIRMENT IN MICE VIA SIGMA(1)-RECEPTORS", Behavioural brain research, 83(1-2), 1997, pp. 159-164

Abstract

We previously reported that high-affinity sigma type 1 (sigma(1)) ligands attenuate the learning impairment induced in mice by dizocilpine,a non-competitive N-methyl-D-aspartate (NMDA) antagonist. Neurosteroids, such as pregnenolone sulfate, progesterone and dehydroepiandrosterone sulfate (DHEAS), modulate NMDA-evoked responses in the central nervous system. Furthermore, some of them were reported to interact with sigma-receptors. This study was carried out to investigate whether DHEAS, a neurosteroid with memory-enhancing effects, attenuates the dizocilpine-induced learning impairment in mice, and, if so, by a mechanisminvolving sigma(1)-receptors. Learning was evaluated using spontaneous alternation in the Y-maze for spatial working memory and step-down type of passive avoidance for long-term memory. At doses about 10-20 mg/kg s.c., DHEAS significantly attenuated dizocilpine (0.15 mg/kg i.p.)-induced impairment of learning on both tests. The enhancing effect ofDHEAS (20 mg/kg s.c.) was antagonized by co-administration of the sigma-antagonist BMY-14802 (5 mg/kg i.p.) and suppressed by a subchronic treatment with haloperidol (4 mg/kg/day s.c. for 7 days). These results indicate that DHEAS attenuates dizocilpine-induced learning impairment via an interaction with sigma(1)-receptors.

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Documento generato il 14/07/20 alle ore 06:57:27