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Titolo:
NEUROPROTECTION OF ACETYLCHOLINERGIC BASAL FOREBRAIN NEURONS BY MEMANTINE AND NEUROKININ-B
Autore:
WENK GL; ZAJACZKOWSKI W; DANYSZ W;
Indirizzi:
UNIV ARIZONA,DIV NEURAL SYST MEMORY & AGING,DEPT PSYCHOL,ARIZONA RES LABS,350 LIFE SCI N TUCSON AZ 85724 UNIV ARIZONA,DIV NEURAL SYST MEMORY & AGING,DEPT NEUROL TUCSON AZ 85724 MERZ & CO GMBH & CO,DEPT PHARMACOL FRANKFURT GERMANY
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 83, anno: 1997,
pagine: 129 - 133
SICI:
0166-4328(1997)83:1-2<129:NOABFN>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONISTS; METHYL-D-ASPARTATE; NUCLEUS BASALIS; GLUTAMATE NEUROTOXICITY; CHOLINERGIC INNERVATION; NERVOUS-SYSTEM; RAT; MEMORY; CORTEX;
Keywords:
MEMANTINE; NUCLEUS BASALIS MAGNOCELLULARIS; ENTORHINAL CORTEX; N-METHYL-D-ASPARTATE; LESION; NEUROKININ B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
G.L. Wenk et al., "NEUROPROTECTION OF ACETYLCHOLINERGIC BASAL FOREBRAIN NEURONS BY MEMANTINE AND NEUROKININ-B", Behavioural brain research, 83(1-2), 1997, pp. 129-133

Abstract

The present study investigated whether chronic, low dose therapy withmemantine could (1) prevent the loss of basal forebrain cholinergic cells induced by injection of N-methyl-D-aspartate (NMDA) into the nucleus basalis magnocellularis (NBM) of rats, and (2) attenuate impaired performance in the radial maze of rats with entorhinal cortex lesions. In addition, we investigated whether neuroprotection could be provided by neurokinin B (NKB). Following an injection of NMDA (0.015 M) intothe NBM, rats were implanted with osmotic minipumps containing memantine (20 or 0.20 mg/kg/day for 2 weeks). Other rats were given unilateral NBM injections of 1.0 mu l of Solution A (0.5 mu l containing 8.26 mM NKB and 0.24 units of bacitracin and 0.5 mu l containing 0.03 M NMDA) or Solution B (0.5 mu l of PBS containing 0.24 U of bacitracin and 0.5 mu l containing 0.03 M NMDA). Two weeks later, the anterior cortexwas analyzed for choline acetyltransferase (ChAT), a specific marker for the loss of acetylcholinergic neurons. Both chronic administrationof memantine, and acute administration of NKB, prevented the decline in cortical ChAT activity associated with injection of NMDA into the NBM, and attenuated a reference memory deficit in the radial maze produced by entorhinal cortex lesions. Thus, memantine infusion at low doses leading to steady-state serum levels within a therapeutic range provides both neuroprotection and cognitive enhancement - an optimal combination for the treatment of neurodegenerative disorders.

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Documento generato il 28/03/20 alle ore 14:17:28