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Titolo:
HUMORAL AND CELLULAR IMMUNE-RESPONSES TO THE FIMBRIAE OF PORPHYROMONAS-GINGIVALIS AND THEIR SYNTHETIC PEPTIDES
Autore:
OGAWA T; OGO H; UCHIDA H; HAMADA S;
Indirizzi:
OSAKA UNIV,FAC DENT,DEPT ORAL MICROBIOL,YAMADAOKA SUITA OSAKA 565 JAPAN
Titolo Testata:
Journal of Medical Microbiology
fascicolo: 6, volume: 40, anno: 1994,
pagine: 397 - 402
SICI:
0022-2615(1994)40:6<397:HACITT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACTEROIDES-GINGIVALIS; PERIODONTAL-DISEASE; SECRETING CELLS; BALB/C MICE; SERUM IGG; ASACCHAROLYTICUS; ANTIBODIES; COLONIZATION; IMMUNIZATION; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
T. Ogawa et al., "HUMORAL AND CELLULAR IMMUNE-RESPONSES TO THE FIMBRIAE OF PORPHYROMONAS-GINGIVALIS AND THEIR SYNTHETIC PEPTIDES", Journal of Medical Microbiology, 40(6), 1994, pp. 397-402

Abstract

Subcutaneous injection of fimbriae from Porphylomonas gingivalis strain 381 in Freund's incomplete adjuvant (FIA) resulted in an excellent serum anti-fimbrial immunoglobulin G (IgG) response in guinea-pigs andBALB/c mice. Administration of P. gingivalis fimbriae also elicited distinct cellular immune responses to the fimbriae in terms of ear lobereaction in BALB/c but not in BALB/c nu/nu mice, and of skin reactionin guineapigs. When the guinea-pigs were given a semi-synthetic adjuvant GM-53-sodium beta-N-acetylglycosaminyl-(l -t 4)-N- l-L-alanyl-D-isoglutaminyl-(L)-stearoyl-(D)meso-2, 6-diaminopimelic acid-(D)-amide-D-alanine-and fimbriae in FIA by subcutaneous injection, more enhanced production of serum anti-fimbrial IgG and stronger cellular immune responses were induced in the guinea-pigs than in those given fimbriae alone. Synthetic peptide FP381(202-221), which corresponds to the amino-acid residue numbers 202-221 based on the amino-acid sequence of fimbrilin from P. gingivalis strain 381, elicited humoral and cellular immune responses in guinea-pigs immunised with the fimbriae or FP381(202-221). Furthermore, subcutaneous administration of synthetic peptide FP381(61-80) with GM-53 induced lesser degrees of humoral and cellular immune responses in guineapigs than did FP381(202-221). However, when thefimbriae or FP381(61-80) were administered with bovine serum albumin (BSA), markedly elevated levels of specific anti-BSA antibody were seen in the serum of BALB/c mice. These results clearly indicated that fimbriae from P. gingivalis 381 and their oligopeptide segments induced humoral and cellular immune responses and exhibited immuno-adjuvant activities in guinea-pigs and BALB/c mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:05:09