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Titolo:
ACETYLCHOLINE DETERMINATION OF CEREBROSPINAL-FLUID IN ANEURYSMAL SUBARACHNOID HEMORRHAGE
Autore:
KAWAMATA T; TAKESHITA M; UJIIE H; SATO K; IZAWA M; KAGAWA M; TAKAKURA K;
Indirizzi:
TOKYO WOMENS MED COLL,INST NEUROL,DEPT NEUROSURG,8-1 KAWADA CHO,SHINJUKU KU TOKYO 162 JAPAN
Titolo Testata:
Surgical neurology
fascicolo: 5, volume: 41, anno: 1994,
pagine: 399 - 404
SICI:
0090-3019(1994)41:5<399:ADOCIA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; RUPTURED INTRACRANIAL ANEURYSMS; EARLY OPERATION; CHOLINE; ISCHEMIA; RATS; NOREPINEPHRINE; ADJUSTMENT; SEROTONIN; DEMENTIA;
Keywords:
ACETYLCHOLINE; CENTRAL CHOLINERGIC ACTIVITY; CEREBROSPINAL FLUID; HPLC-ED; SUBARACHNOID HEMORRHAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T. Kawamata et al., "ACETYLCHOLINE DETERMINATION OF CEREBROSPINAL-FLUID IN ANEURYSMAL SUBARACHNOID HEMORRHAGE", Surgical neurology, 41(5), 1994, pp. 399-404

Abstract

Acetylcholine (ACh) concentrations were determined serially in cerebrospinal fluid (CSF) obtained from 23 patients with aneurysmal subarachnoid hemorrhage (SAH) by high-performance liquid chromatography (HPLC)with electrochemical detection (ED). The values of CSF ACh were significantly low in the initial stage of SAH, and increased subsequently but they did not return to control values within 3 weeks. In addition, serial measurements of CSF butyrylcholinesterase (BChE) activity in 12SAH patients showed that the activity was elevated significantly in the initial stage of SAH and returned to control levels within a week. This discrepancy in the recovery period between the ACh levels and theBChE activity in CSF indicated that significantly lower CSF ACh levels after SAH could not be attributed to plasma BChE contamination of CSF. These results suggested central cholinergic dysfunction after SAH, especially in the initial stage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:13:05