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Titolo:
3 DISTINCT HUMAN THYMOPOIETINS ARE DERIVED FROM ALTERNATIVELY SPLICEDMESSENGER-RNAS
Autore:
HARRIS CA; ANDRYUK PJ; CLINE S; CHAN HK; NATARAJAN A; SIEKIERKA JJ; GOLDSTEIN G;
Indirizzi:
IMMUNOBIOL RES INST ANNANDALE NJ 08801
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 14, volume: 91, anno: 1994,
pagine: 6283 - 6287
SICI:
0027-8424(1994)91:14<6283:3DHTAD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID SEQUENCE; POLYPEPTIDE HORMONE; DOUBLE-BLIND; THYMOPENTIN; PROTEINS; THYMUS; EXPRESSION; SITES;
Keywords:
THYMIC PROTEINS; NUCLEAR PROTEINS; ALTERNATIVE SPLICING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Harris et al., "3 DISTINCT HUMAN THYMOPOIETINS ARE DERIVED FROM ALTERNATIVELY SPLICEDMESSENGER-RNAS", Proceedings of the National Academy of Sciences of the United Statesof America, 91(14), 1994, pp. 6283-6287

Abstract

Thymopoietin (TP) was originally isolated as a 5-kDa 49-aa protein from bovine thymus in studies of the effects of thymic extracts on neuromuscular transmission and was subsequently observed to affect T-cell differentiation and function. We now report the isolation of cDNA clones for three alternatively spliced mRNAs that encode three distinct human T-cell TPs. Proteins encoded by these mRNAs, which we have named TPalpha (75 kDa), TP beta (51 kDa), and TP gamma (39 kDa), contain identical N-terminal regions, including sequences nearly identical to thatof the originally isolated 49-aa protein, but divergent C-terminal regions. TP mRNAs are expressed in many tissues, most abundantly in adult thymus and fetal liver of the tissues so far examined. Distinct structural domains and functional motifs in TPs alpha, beta, and gamma suggest that the proteins have unique functions and may be directed to distinct subcellular compartments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:15:32