Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COMPARATIVE EFFECTS OF THE DIHYDROPYRIDINE-TYPE CALCIUM-AGONISTS (-)-S-BAY-K-8644, (+ -)-BAY-W-5035 AND (+/-)-BAY-T-5006 ON HUMAN PLATELET AGGREGABILITY/
Autore:
RUMP AFE; BOLLER M; BERKELS R; ROSEN R; FRICKE U; KLAUS W;
Indirizzi:
UNIV COLOGNE,INST PHARMAKOL W-5000 COLOGNE GERMANY
Titolo Testata:
General pharmacology
fascicolo: 3, volume: 25, anno: 1994,
pagine: 447 - 450
SICI:
0306-3623(1994)25:3<447:CEOTDC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACORPOREAL-CIRCULATION; CHANNELS; PROSTAGLANDIN-H2; THROMBOXANE-A2; AGGREGATION; NIFEDIPINE; ACTIVATION; FIBRINOGEN; VERAPAMIL; RECEPTOR;
Keywords:
THROMBOCYTES; PLATELET INHIBITION; DIHYDROPYRIDINES; CALCIUM-AGONISTS; BAY-K 8644; BAY-W 5035; BAY-T 5006;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A.F.E. Rump et al., "COMPARATIVE EFFECTS OF THE DIHYDROPYRIDINE-TYPE CALCIUM-AGONISTS (-)-S-BAY-K-8644, (+ -)-BAY-W-5035 AND (+/-)-BAY-T-5006 ON HUMAN PLATELET AGGREGABILITY/", General pharmacology, 25(3), 1994, pp. 447-450

Abstract

1. Human platelet aggregation induced by collagen is concentration-dependently inhibited by dihydropyridine (DHP)-type calcium(Ca)-agonists. 2. There was no significant difference between the maximal anti-aggregatory effects or the antiaggregatory potencies of (-)-S-Bay-K 8644 (EC(50): 5.3 +/- 1.5 x 10(-5) M), (+/-)-Bay-W 5035 (EC(50): 14.9 +/- 8.8 x 10(-5) M) or (+/-)-Bay-T 5006 (EC(50): 2.7 +/- 1.9 x 10(-5) M) (P > 0.05). 3. Antiaggregatory effects of DHP-type Ca-agonists seem to beindependent of Ca-channel activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:35:48