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Titolo:
PROTECTION OF ATRIAL FUNCTION IN HYPOXIA BY HIGH POTASSIUM CONCENTRATION
Autore:
FROLDI G; PANDOLFO L; CHINELLATO A; RAGAZZI E; CAPARROTTA L; FASSINA G;
Indirizzi:
UNIV PADUA,DEPT PHARMACOL,LARGO E MENEGHETTI 2 I-35131 PADUA ITALY
Titolo Testata:
General pharmacology
fascicolo: 3, volume: 25, anno: 1994,
pagine: 401 - 407
SICI:
0306-3623(1994)25:3<401:POAFIH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE K+ CHANNELS; CARDIAC-MUSCLE; HIBERNATING MYOCARDIUM; OPENERS; CA-2+; REOXYGENATION; GLIBENCLAMIDE; PHARMACOLOGY; HYPERTENSION; REPERFUSION;
Keywords:
HYPOXIA; POTASSIUM; GLIBENCLAMIDE; ATRIAL FUNCTION; ENERGY METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
G. Froldi et al., "PROTECTION OF ATRIAL FUNCTION IN HYPOXIA BY HIGH POTASSIUM CONCENTRATION", General pharmacology, 25(3), 1994, pp. 401-407

Abstract

1. The effects of high extracellular potassium on hypoxia-induced atrial activity and metabolic charge were studied in isolated rat atria. 2. After hypoxia (30 min), contractile tension strongly decreased and diastolic tension increased, while frequency did not change. Adenine nucleotides and creatine phosphate levels did not change, although a significant increase in lactic acid content was observed. 3. High [K+] mostly countered the hypoxia-induced increase in diastolic tension. Moreover, in the presence of high [K+], the hypoxia-induced increase in lactic acid was not significantly different from normoxic controls. 4. Glibenclamide (0.1 mu M), a selective K-ATP(+) channel blocker, did not improve the hypoxia-induced depression of atrial function. 5. The physiopathological role of extracellular potassium during cardiac hypoxia is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:20:50