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Titolo:
CEREBRAL DOPAMINE AND NORADRENALINE IN MICE WITHDRAWN FROM REPEATED MORPHINE TREATMENT AND DEVELOPMENT OF TOLERANCE TO A TEST DOSE OF MORPHINE
Autore:
ETEMADZADEH E;
Indirizzi:
ORION FARMOS PHARMACEUT,RES CTR,DEPT PHARMACOL & TOXICOL SF-02101 ESPOO FINLAND UNIV HELSINKI,DEPT PHARM,DIV PHARMACOL & TOXICOL SF-00170 HELSINKI FINLAND
Titolo Testata:
General pharmacology
fascicolo: 4, volume: 25, anno: 1994,
pagine: 623 - 629
SICI:
0306-3623(1994)25:4<623:CDANIM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED INCREASES; OPIATE AGONISTS; MOUSE BRAIN; RATS; RELEASE; CAUDATE; TURNOVER; NALOXONE; NUCLEUS; DELTA;
Keywords:
DOPAMINE; NORADRENALINE; CATECHOLAMINES; MORPHINE; TOLERANCE; ALPHA-METHYL-RHO-TYROSINE (ALPHA-M-RHO-T);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
E. Etemadzadeh, "CEREBRAL DOPAMINE AND NORADRENALINE IN MICE WITHDRAWN FROM REPEATED MORPHINE TREATMENT AND DEVELOPMENT OF TOLERANCE TO A TEST DOSE OF MORPHINE", General pharmacology, 25(4), 1994, pp. 623-629

Abstract

1. In mice withdrawn from 3 days of morphine, dopamine depletion was significantly (P < 0.01) retarded in the ''rest of the forebrain and midbrain'' and tended to be retarded in the striatum. 2. In control mice withdrawn from 3 days of saline treatment a 10mg/kg test dose of morphine significantly enhanced noradrenaline depletion in all selected brain areas. This did not occur in test mice withdrawn from 1-3 days ofmorphine, indicating development of tolerance. 3. These results suggest that dopamine depletion is retarded in the ''rest of the forebrain and midbrain'' of mice withdrawn from 3 days of repeated morphine and that noradrenaline depletion is unchanged in all selected brain areas of mice withdrawn from morphine. 4. Tolerance develops to the enhancing effect of morphine on noradrenaline depletion in mice withdrawn from3 days of repeated morphine but not in those withdrawn from 1 day of treatment only.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:27:58