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Titolo:
SCREENING MATERNAL SERUM ALPHA-FETOPROTEIN LEVELS AND HUMAN PARVOVIRUS ANTIBODIES
Autore:
JOHNSON DR; FISHER RA; HELWICK JJ; MURRAY DL; PATTERSON MJ; DOWNES FP;
Indirizzi:
MICHIGAN DEPT PUBL HLTH,BUR INFECT DIS CONTROL,3500 N LOGAN MLK JR BLVD,POB 30035 LANSING MI 48909 CTR DIS CONTROL,DIV FIELD EPIDEMIOL ATLANTA GA 30333 MICHIGAN STATE UNIV,DEPT PEDIAT & HUMAN DEV E LANSING MI 48824
Titolo Testata:
Prenatal diagnosis
fascicolo: 6, volume: 14, anno: 1994,
pagine: 455 - 458
SICI:
0197-3851(1994)14:6<455:SMSALA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROPS-FETALIS SECONDARY; B19 INFECTION; PREGNANCY;
Keywords:
HUMAN PARVOVIRUS B19; PRENATAL SCREENING; MATERNAL SERUM ALPHA-FETOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Johnson et al., "SCREENING MATERNAL SERUM ALPHA-FETOPROTEIN LEVELS AND HUMAN PARVOVIRUS ANTIBODIES", Prenatal diagnosis, 14(6), 1994, pp. 455-458

Abstract

The association between gestational infection with human parvovirus (B19) and fetal loss has increased interest in this virus and demand for diagnostic testing. However, serological assays for B19 are not yet widely available. Maternal serum alpha-fetoprotein (MSAFP) testing is commonly used during the second trimester to screen for various fetal defects. We attempted to determine whether an elevated level of MSAFP would be an appropriate indication for B19-specific tests. Over a 26-month period, MSAFP tests were performed at Michigan State University for 21 392 women. Sera remaining after that testing were stored frozen. Of these, 22 case samples-from women with MSAFP levels greater than 3.0 multiples of the median (MOM) and pregnancies that ended in fetal loss-and 44 matched control samples-from women with MSAFP levels greater than 0.4 and less than 22 MOM and live births at term-were tested for B19 antibodies. None of the 66 samples was IgM positive, while 33 (50 per cent) were IgG positive. The presence of IgG was not significantly associated with case or control status (matched odds ratio = 0.77, 95 per cent confidence interval 0.28-2.11). These findings are consistent with other studies indicating prior infection in approximately half of adults and suggest that elevated screening MSAFP levels, in the absence of other evidence of B19 infection, should not prompt B19-specific testing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:39:51