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Titolo:
AGNOR CONTENT AND PCNA EXPRESSION IN TRANSPLANTED MALIGNANT NEURINOMAIN RATS
Autore:
MENNEL HD; RICKERT D;
Indirizzi:
PHILIPPS UNIV MARBURG,MED CTR PATHOL,DEPT NEUROPATHOL,BALDINGERSTR D-35043 MARBURG GERMANY
Titolo Testata:
Pathology research and practice
fascicolo: 5, volume: 190, anno: 1994,
pagine: 423 - 428
SICI:
0344-0338(1994)190:5<423:ACAPEI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOLAR ORGANIZER REGIONS; CELL NUCLEAR ANTIGEN; HUMAN BRAIN-TUMORS; PROLIFERATION; CLASSIFICATION; PROTEINS; NORS;
Keywords:
NUCLEOLUS ORGANIZER REGIONS (AGNORS); PROLIFERATIVE CELL NUCLEAR ANTIGEN (PCNA); EXPERIMENTAL RAT TUMORS; MALIGNANT NEURINOMA GRAFTS; PROLIFERATION MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
H.D. Mennel e D. Rickert, "AGNOR CONTENT AND PCNA EXPRESSION IN TRANSPLANTED MALIGNANT NEURINOMAIN RATS", Pathology research and practice, 190(5), 1994, pp. 423-428

Abstract

Malignant neurinomas can be induced in BD IX rats by transplacental application of ethylnitroso-urea during pregnancy. Tumors develop in the offspring in trigeminal and spinal nerves and can be easily transplanted upon rats of the same strain. During the first passages a considerable shortening of subsequent induction periods takes place. Concurrently, silver stained Nucleolar Organizer Regions (AgNORs) increase in number and other measured AgNOR parameters change in a similar way. The number of cells that express the proliferation marker PCNA equally becomes more frequent during the first subcutaneously transplanted generations. There is high correlation between AgNOR parameters, number ofPCNA expressing cells, induction times and passage. It is concluded that the first generations of the transplantation model of these tumorscan be used to test the validity of proliferation indicators. Our results show further that AgNORs in fact belong to the group of markers of proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 16:57:09