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Titolo:
PAPILLOMAVIRUS-ASSOCIATED FOCAL ORAL HYPERPLASIA IN WILD AND CAPTIVE ASIAN LIONS (PANTHERA LEO PERSICA)
Autore:
SUNDBERG JP; MONTALI RJ; BUSH M; PHILLIPS LG; OBRIEN SJ; JENSON AB; BURK RD; VANRANST M;
Indirizzi:
JACKSON LAB,600 MAIN ST BAR HARBOR ME 04609 SMITHSONIAN INST,NATL ZOOL PK WASHINGTON DC 20008 UNIV CALIF DAVIS,SCH VET MED DAVIS CA 92112 NCI,NIH FREDERICK MD 21702 GEORGETOWN UNIV,SCH MED WASHINGTON DC 20007 CATHOLIC UNIV LEUVEN,REGA INST MED RES B-3000 LOUVAIN BELGIUM YESHIVA UNIV ALBERT EINSTEIN COLL MED NEW YORK NY 10461
Titolo Testata:
Journal of zoo and wildlife medicine
fascicolo: 1, volume: 27, anno: 1996,
pagine: 61 - 70
SICI:
1042-7260(1996)27:1<61:PFOHIW>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FELINE HERPESVIRUS TYPE-1; PYGMY CHIMPANZEE; INFECTION; CHEETAH; VIRUS; SKIN; MICE; LESIONS; CAT;
Keywords:
PAPILLOMAVIRUS; ASIAN LION; PANTHERA LEO PERSICA; FELIDAE; PIPV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Sundberg et al., "PAPILLOMAVIRUS-ASSOCIATED FOCAL ORAL HYPERPLASIA IN WILD AND CAPTIVE ASIAN LIONS (PANTHERA LEO PERSICA)", Journal of zoo and wildlife medicine, 27(1), 1996, pp. 61-70

Abstract

Four Asian lions (Panthera leo persica), two wild and two captive, were diagnosed with focal oral hyperplasia affecting the ventral surfaceof their tongues. Focal, flat, sessile lesions consisted of hyperplastic, stratified squamous epithelium. Koilocytotic atypia was evident in the upper layers of cells, some of which contained characteristic intranuclear papillomavirus particles visible by electron microscopy. Inaddition, large amphophilic cytoplasmic inclusions were evident in the koilocytes and were considered to be a product of the viral E4 gene. Papillomavirus group-specific antigens were detected by immunohistochemistry in the atypical cell nuclei. Conserved papillomavirus antigenic epitopes differed from epitopes found in cutaneous papillomavirus-induced lesions from domestic cats. An 8,000-base pair DNA fragment, linearized by Bam HI digestion, was detected by Southern blot hybridization probed with a mixed human papillomavirus genomic probe. Limited restriction endonuclease studies of DNA prepared using an oral hyperplastic lesion from an Asian lion indicate that this is a novel feline papillomavirus different from the domestic cat cutaneous papillomavirus. This new virus has been designated ''PLPV.''

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:28:08