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Titolo:
GLUCAGON-LIKE PEPTIDE-1 7-36-AMIDE AND PEPTIDE-YY FROM THE L-CELL OF THE ILEAL-MUCOSA ARE POTENT INHIBITORS OF VAGALLY INDUCED GASTRIC-ACIDSECRETION IN MAN
Autore:
WETTERGREN A; PETERSEN H; ORSKOV C; CHRISTIANSEN J; SHEIKH SP; HOLST JJ;
Indirizzi:
UNIV COPENHAGEN,RIGSHOSP,DEPT GASTROINTESTINAL SURG C DK-2100 COPENHAGEN O DENMARK GLOSTRUP CTY HOSP,DEPT GASTROINTESTINAL SURG D DK-2600 GLOSTRUP DENMARK UNIV COPENHAGEN,MOLEC ENDOCRINOL LAB COPENHAGEN DENMARK UNIV COPENHAGEN,RIGSHOSP,DEPT CLIN CHEM DK-2100 COPENHAGEN DENMARK UNIV COPENHAGEN,INST MED PHYSIOL COPENHAGEN DENMARK
Titolo Testata:
Scandinavian journal of gastroenterology
fascicolo: 6, volume: 29, anno: 1994,
pagine: 501 - 505
SICI:
0036-5521(1994)29:6<501:GP7APF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITES; RAT-BRAIN; PROGLUCAGON; GLICENTIN; RELEASE; GUT;
Keywords:
ACID SECRETION; GLUCAGON-LIKE PEPTIDE-1; PEPTIDE YY; SHAM FEEDING; VAGAL NERVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A. Wettergren et al., "GLUCAGON-LIKE PEPTIDE-1 7-36-AMIDE AND PEPTIDE-YY FROM THE L-CELL OF THE ILEAL-MUCOSA ARE POTENT INHIBITORS OF VAGALLY INDUCED GASTRIC-ACIDSECRETION IN MAN", Scandinavian journal of gastroenterology, 29(6), 1994, pp. 501-505

Abstract

Background: Glucagon-like peptide (GLP-1) 7-36 amide and peptide YY (PYY) from the L-cell of the ileal mucosa are potent inhibitors of gastric acid secretion in man. It is not clear, however, by which mechanism(s) they inhibit acid secretion. In dogs the inhibitory effect of PYYon acid secretion may be mediated mainly through neural pathways. Themechanism of action of GLP-1 might be similar. The aim of the presentstudy was to examine the effects of GLP-1 might be similar. The aim of the present study was to examine the effects of GLP-1 and PW on the vagally induced gastric acid secretion in man. Methods: A modified sham feeding technique, chew and spit, was used. Six healthy volunteers were randomly assigned to receive intravenous infusion of saline, GLP-1(41 pmol/kg/h), or peptide W (50 pmol/kg/h). Results: The infusion ofGLP-1 and PW resulted in plasma concentrations of 60 +/- 9 pmol/l and84 +/- 11 pmol/l, respectively. GLP-1 and PYY both significantly inhibited the integrated acid output by 67 +/- 6% and 68 +/- 9%, respectively, compared with the integrated outputs in a control experiment withsaline infusion. Serum gastrin and plasma somatostatin concentrationsremained unchanged during saline, GLP-1, and PW infusions. Conclusions: GLP-1 and PYY are both potent inhibitors of the cephalic phase of acid secretion, indicating that at least part of the inhibitory effect of GLP-1 and PW in man is mediated through neural pathways. Furthermore, the inhibitory effect seems to be independent of circulating concentrations of gastrin and somatostatin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:57:20