Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SYSTEMIC AND MYOCARDIAL EFFECTS OF ATP AND ADENOSINE DURING HYPOXIC PULMONARY-HYPERTENSION IN LAMBS
Autore:
KONDURI GG;
Indirizzi:
HUTZEL HOSP,CHILDRENS HOSP MICHIGAN,DEPT PEDIAT,4707 ST ANTOINE BLVD DETROIT MI 48201 WAYNE STATE UNIV,SCH MED,DEPT PEDIAT DETROIT MI 48201
Titolo Testata:
Pediatric research
fascicolo: 1, volume: 36, anno: 1994,
parte:, 1
pagine: 41 - 48
SICI:
0031-3998(1994)36:1<41:SAMEOA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEWBORN LAMBS; FETAL LAMBS; BLOOD-FLOW; OXYGEN-CONSUMPTION; TRIPHOSPHATE; VASODILATION; CIRCULATION; TOLAZOLINE; TRANSPORT; HYPOXEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
G.G. Konduri, "SYSTEMIC AND MYOCARDIAL EFFECTS OF ATP AND ADENOSINE DURING HYPOXIC PULMONARY-HYPERTENSION IN LAMBS", Pediatric research, 36(1), 1994, pp. 41-48

Abstract

The systemic and myocardial effects of adenosine and ATP were investigated in 12 newborn lambs, instrumented at 5-7 d of age with cathetersin the aorta, pulmonary artery, coronary sinus, and right and left atria and flow transducers around the main pulmonary artery and left circumflex coronary artery. Studies were done 3-7 d after recovery from surgery. Pulmonary hypertension was induced by exposure to alveolar hypoxia (10% O-2, 5% CO2, and 85% N-2), which was maintained throughout the experiment. Adenosine, ATP, or an equal volume of saline (control) was infused into the right atrial line in doses of 0.04 to 2.5 mu mol/kg/min during hypoxia. Alveolar hypoxia caused significant increases in pulmonary artery pressure, pulmonary vascular resistance, left circumflex flow, left ventricular O-2 consumption, and systemic and myocardial O-2 extraction and a decrease in systemic O-2 transport. ATP and adenosine caused selective decreases in pulmonary artery pressure and pulmonary vascular resistance at doses of 0.04 to 0.30 mu mol/kg/min and decreases in both pulmonary and systemic pressures and resistances at 0.60 to 2.5 mu mol/kg/min. ATP and adenosine caused increases in systemic O-2 transport, left circumflex flow, left ventricular O-2 transport, and left ventricular O-2 consumption and decreases in systemic O-2 extraction and left ventricular O-2 extraction at 0.3 to 2.5 mu mol/kg/min. Systemic O-2 consumption did not change during the study. Arterial and coronary sinus blood lactate levels increased during hypoxia and decreased from hypoxia at 2.5-mu mol/kg/min infusion rates of adenosine and ATP. Adenosine and ATP cause selective pulmonary vasodilation in lambs with pulmonary hypertension at doses of 0.04 to 0.30 mu mol/kg/min and improvement in systemic and myocardial O-2 delivery at larger doses. Adenosine and ATP may have a beneficial role in the management of pulmonary hypertension in children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:44:35