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Titolo:
AN INHIBITOR OF PROTEIN-PHOSPHORYLATION STOPS THE CIRCADIAN OSCILLATOR AND BLOCKS LIGHT-INDUCED PHASE-SHIFTING IN GONYAULAX-POLYEDRA
Autore:
COMOLLI J; TAYLOR W; HASTINGS JW;
Indirizzi:
HARVARD UNIV,DEPT CELLULAR & MOLEC BIOL,BIOL LABS,16 DIVINITY AVE CAMBRIDGE MA 02138 HARVARD UNIV,DEPT CELLULAR & MOLEC BIOL,BIOL LABS CAMBRIDGE MA 02138
Titolo Testata:
Journal of biological rhythms
fascicolo: 1, volume: 9, anno: 1994,
pagine: 13 - 26
SICI:
0748-7304(1994)9:1<13:AIOPST>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNICELLULAR ALGA; CELL-DIVISION; CLOCK; 6-DIMETHYLAMINOPURINE; KINASE; PACEMAKER; TRANSITION; MEDIATE; RHYTHMS; OOCYTE;
Keywords:
PROTEIN KINASE; 6-DIMETHYLAMINOPURINE; 6-DMAP; PHOSPHORYLATION; DINOFLAGELLATE; CIRCADIAN; GONYAULAX; PHASE SHIFTING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J. Comolli et al., "AN INHIBITOR OF PROTEIN-PHOSPHORYLATION STOPS THE CIRCADIAN OSCILLATOR AND BLOCKS LIGHT-INDUCED PHASE-SHIFTING IN GONYAULAX-POLYEDRA", Journal of biological rhythms, 9(1), 1994, pp. 13-26

Abstract

The expression of circadian rhythmicity in Gonyaulax polyedra is strikingly altered by an inhibitor of protein phosphorylation. The effectsof 6-dimethylaminopurine (6-DMAP), known to reversibly block cell division in many systems through inhibition of protein kinase activity, are described here for Gonyaulax, Its action appears to be exclusively tonic in nature; in cells continuously exposed, the period is lengthened in a concentration-dependent fashion. Shorter treatments at a higher concentration of 6-DMAP (5 mM) apparently stop the circadian oscillator, but reversibly so, since the rhythm resumes after drug removal with a phase delay approximately equal to the duration of the treatment. Pulses of the inhibitor are effective in causing phase delays at all times of the circadian cycle. In addition, 6-DMAP completely blocks light-induced phase advances and is effective in inhibiting many Gonyaulax protein kinases in vitro.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 03:36:42