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Titolo:
SUCCESSFUL ADENOVIRUS-MEDIATED GENE-TRANSFER IN AN IN-VIVO MODEL OF HUMAN-MALIGNANT MESOTHELIOMA
Autore:
SMYTHE WR; KAISER LR; HWANG HC; AMIN KM; PILEWSKI JM; ECK SJ; WILSON JM; ALBELDA SM;
Indirizzi:
HOSP UNIV PENN,THORAC ONCOL RES LAB,36TH SPRUCE,MALONEY BLDG,RM 809 PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT SURG,THORAC SURG SECT,THORAC ONCOL RES LAB PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT MED,PULM CRIT CARE SECT PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT MOLEC & CELLULAR ENGN PHILADELPHIA PA 19104 UNIV PENN,MED CTR,INST HUMAN GENE THERAPY PHILADELPHIA PA 19104
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 6, volume: 57, anno: 1994,
pagine: 1395 - 1401
SICI:
0003-4975(1994)57:6<1395:SAGIAI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIDINE KINASE GENES; EXTRAPLEURAL PNEUMONECTOMY; PLEURAL MESOTHELIOMA; TUMORS; VECTORS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
W.R. Smythe et al., "SUCCESSFUL ADENOVIRUS-MEDIATED GENE-TRANSFER IN AN IN-VIVO MODEL OF HUMAN-MALIGNANT MESOTHELIOMA", The Annals of thoracic surgery, 57(6), 1994, pp. 1395-1401

Abstract

Malignant mesothelioma remains a frustrating clinical problem with uniformly poor responses to current therapeutic regimens. However, the localized nature of the disease, the potential accessibility of the tumor, and the relative lack of distant metastases make it a particularlyattractive candidate for somatic gene therapy. The purpose of this study was to evaluate the ability of an adenoviral vector system to transfer genetic material to human mesothelioma cells in vitro and in vivo. Using a replication-deficient recombinant adenovirus carrying the Escherichia coli lacZ marker gene, we found that human mesothelioma celllines were susceptible to adenovirus infection, Furthermore, surprisingly effective gene transfer was accomplished within tumor implants ofhuman mesothelioma growing within the peritoneal cavity of immunodeficient mice after intraperitoneal administration of virus. These studies demonstrate that adenoviral vectors hold promise as vehicles to deliver gene therapy in human malignant mesothelioma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:39:08