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Titolo:
CRANIAL BASE SURGERY - RESULTS IN 183 PATIENTS
Autore:
JANECKA IP; SEN C; SEKHAR LN; RAMASASTRY S; CURTIN HD; BARNES EL; DAMICO F;
Indirizzi:
UNIV PITTSBURGH,MED CTR,SCH MED,CTR CRANIAL BASE SURG,203 LOTHROP ST,SUITE 500 PITTSBURGH PA 15213 MT SINAI MED CTR NEW YORK NY 10029 GEORGE WASHINGTON UNIV,MED CTR WASHINGTON DC 20037 DUQUESNE UNIV,DEPT MATH & COMP SCI PITTSBURGH PA 00000
Titolo Testata:
Otolaryngology and head and neck surgery
fascicolo: 6, volume: 110, anno: 1994,
pagine: 539 - 546
SICI:
0194-5998(1994)110:6<539:CBS-RI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKULL BASE; ANTERIOR; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
I.P. Janecka et al., "CRANIAL BASE SURGERY - RESULTS IN 183 PATIENTS", Otolaryngology and head and neck surgery, 110(6), 1994, pp. 539-546

Abstract

OBJECTIVE: To learn about the effects of cranial base surgery. DESIGN: Cohort study with a mean follow-up of 30 months. SETTING: Population-based. PATIENTS: A consecutive sample of 183 patients who underwent cranial base surgery; 118 patients had malignant skull base tumors, themajority of which were previously treated; 50 had benign tumors; 9 had congenital malformations of the skull base; 3 had inflammatory lesions, and 3 had traumatic defects of the skull base. MAIN OUTCOME MEASURES: Disease-free interval, overall survival, and rate of complicationsand functional status. INTERVENTION: Cranial base surgery was followed by radiotherapy (in previously untreated patients). RESULTS: After completion of follow-up (mean, 30 months), 30 (25.4%) patients had diedof their malignant tumors and 8 (6.8%) had died of other causes. One patient (0.84%) was lost to follow-up. The overall cancer survival rate without regard to histologic type was 67% (63% with no evidence of disease). Among the patients who were treated for benign neoplasm, 72% had no evidence of disease at a mean follow-up of 39 months. The groupof patients with congenital malformations and inflammatory and traumatic lesions demonstrated successful correction of their presurgical problem with skull base surgery. One patient (who had invasive aspergillosis) died of disease. The overall surgical-medical mortality rate was2%; the complication rate was 33%, and the Karnofsky performance score was improved or unchanged after surgery in 83% of patients. The average duration of surgery, number of blood transfusions used, and lengthof the hospital stay were 10 hours, 3 units, and 15 days, respectively. CONCLUSIONS: Cranial base surgery is a valid surgical technique fortreatment of cranial base afflictions. In this study it was found to be beneficial in controlling benign and malignant disease and to be the treatment of choice for selected congenital malformations, trauma, and inflammatory lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:12:38