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Titolo:
EFFECTS OF PULMONARY FIBROSIS ON THE DISTRIBUTION OF EDEMA - COMPUTEDTOMOGRAPHIC SCANNING AND MORPHOLOGY
Autore:
ZWIKLER MP; PETERS TM; MICHEL RP;
Indirizzi:
MCGILL UNIV,DEPT PATHOL,3775 UNIV ST,RM 719 MONTREAL H3A 2B4 PQ CANADA MCGILL UNIV,DEPT PATHOL MONTREAL H3A 2B4 PQ CANADA MCGILL UNIV,MONTREAL NEUROL INST MONTREAL PQ CANADA ROYAL VICTORIA HOSP MONTREAL H3A 1A1 PQ CANADA
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 5, volume: 149, anno: 1994,
pagine: 1266 - 1275
SICI:
1073-449X(1994)149:5<1266:EOPFOT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
REGIONAL BLOOD-VOLUME; DOG LUNG; DENSITY; PERMEABILITY; PRESSURE; INJURY; FLOW; RESISTANCE; FAILURE; OXYGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
M.P. Zwikler et al., "EFFECTS OF PULMONARY FIBROSIS ON THE DISTRIBUTION OF EDEMA - COMPUTEDTOMOGRAPHIC SCANNING AND MORPHOLOGY", American journal of respiratory and critical care medicine, 149(5), 1994, pp. 1266-1275

Abstract

The pulmonary interstitium acts as an important safety factor againstalveolar flooding. To test the hypothesis that in advanced fibrosis, edema is redistributed away from a less compliant interstitium to flood alveoli, we induced severe left lung fibrosis in six dogs with radiation and intratracheal bleomycin. Twenty-four months later, edema was induced by infusing 20% body weight lactated Ringer's solution over 30min, preceded and followed by computed tomography (CT) scanning. Lower robes were frozen, and samples were taken for extravascular lung water measurements (QwI/dQI), regional blood volume, and light microscopic grading of interstitial and alveolar edema. The total volumes of thecontrol and fibrotic lungs were 800 +/- 63 and 45 +/- 10 ml(SE), respectively, indicative of severe fibrosis. Before edema, the fibrotic carinal and basal slices had CT densities 3.5 and 2.2 times greater thanrespective control slices. After edema, the densities of all control lung slices rose 2.5 times and that of fibrotic carinal and basal slices rose 1.5 times. Edema significantly accentuated the small gravity-dependent gradient in CT density of control lungs, but it had minimal effect on this gradient in fibrotic lungs. The QwI/dQI for control and fibrotic lower lobes were 8.7 +/- 0.8 and 6.8 +/- 0.7 g H2O/g dry lung, respectively, but the amounts of water per lung volume were similar,and there was no gravity-dependent gradient in QwI/dQI or in regionalblood contents. By light microscopy, we found significantly less interstitial and more alveolar edema in the fibrotic robes. We conclude that in severe pulmonary fibrosis, similar amounts of water accumulate per lung volume as in controls, and that there is predominant alveolar flooding over interstitial edema. We also conclude that the gravity-dependent gradients in CT densities postedema in the control lungs are not accounted for by edema fluid or congestion, but probably by atelectasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:00:18