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Titolo:
INTERLEUKIN-6 SECRETION BY MONOCYTES AND ALVEOLAR MACROPHAGES IN SYSTEMIC-SCLEROSIS WITH LUNG INVOLVEMENT
Autore:
CRESTANI B; SETA N; DEBANDT M; SOLER P; ROLLAND C; DEHOUX M; BOUTTEN A; DOMBRET MC; PALAZZO E; KAHN MF; AUBIER M;
Indirizzi:
HOP BICHAT,UNITE PNEUMOL,46 RUE HENRI HUCHARD F-75018 PARIS FRANCE HOP BICHAT,INSERM,U226 PARIS FRANCE HOP BICHAT,INSERM,U82 PARIS FRANCE HOP BICHAT,SERV PNEUMOL F-75877 PARIS FRANCE HOP BICHAT,SERV RHEUMATOL F-75877 PARIS FRANCE HOP BICHAT,BIOCHIM LAB A F-75877 PARIS FRANCE
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 5, volume: 149, anno: 1994,
pagine: 1260 - 1265
SICI:
1073-449X(1994)149:5<1260:ISBMAA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; BRONCHOALVEOLAR LAVAGE; MONONUCLEAR-CELLS; SYNOVIAL-FLUID; SCLERODERMA; DISEASE; SERUM; IL-6; INFLAMMATION; PATHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
B. Crestani et al., "INTERLEUKIN-6 SECRETION BY MONOCYTES AND ALVEOLAR MACROPHAGES IN SYSTEMIC-SCLEROSIS WITH LUNG INVOLVEMENT", American journal of respiratory and critical care medicine, 149(5), 1994, pp. 1260-1265

Abstract

Interleukin-6 (IL-6) has been involved in the pathogenesis of inflammatory and/or autoimmune diseases. We characterized the production of IL-6 by blood monocytes and alveolar macrophages (AM) in 11 patients with definite systemic sclerosis (SSc) with lung involvement and in eight normal control subjects. IL-6 levels were determined in serum, bronchoalveolar lavage (BAL) supernatants, monocytes, and AM cell culture supernatants using an ELISA kit. BAL cell analysis evidenced an alveolitis with hypercellularity and increased neutrophils and mast cells absolute counts. Serum and BAL IL-6 levels were low and similar in SSc and control groups. The monocytes of the group with SSc secreted more IL-6 than did the control group, both spontaneously (p = 0.01) and afterLPS stimulation (p = 0.0007). Spontaneous secretion of IL-6 by AM tended to be higher in the SSc group than in the control group (p = 0.22). LPS-induced IL-6 secretion by AM was similar in both groups. Our study demonstrates that during SSc rung disease, spontaneous and stimulated IL-6 secretion by blood monocytes is increased, compared with secretion by healthy control subjects. By contrast, IL-6 secretion by AM isnormal despite evidence of mild alveolitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:14:38