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Titolo:
MAPPING OF THE SYNDECAN GENES IN THE MOUSE - LINKAGE WITH MEMBERS OF THE MYC GENE FAMILY
Autore:
SPRING J; GOLDBERGER OA; JENKINS NA; GILBERT DJ; COPELAND NG; BERNFIELD M;
Indirizzi:
HARVARD UNIV,SCH MED,JOINT PROGRAM NEONATOL,300 LONGWOOD AVE,ENDERS 9BOSTON MA 02115 HARVARD UNIV,SCH MED,JOINT PROGRAM NEONATOL BOSTON MA 02115 NCI,FREDERICK CANC RES & DEV CTR,ABL,MAMMALIAN GENET LAB,BASIC RES PROGRAM FREDERICK MD 21702
Titolo Testata:
Genomics
fascicolo: 3, volume: 21, anno: 1994,
pagine: 597 - 601
SICI:
0888-7543(1994)21:3<597:MOTSGI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPARAN-SULFATE PROTEOGLYCAN; MOLECULAR-CLONING; CORE PROTEINS; EXPRESSION; LOCALIZATION; EVOLUTION; MAP; ORGANIZATION; SEQUENCE; GENOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J. Spring et al., "MAPPING OF THE SYNDECAN GENES IN THE MOUSE - LINKAGE WITH MEMBERS OF THE MYC GENE FAMILY", Genomics, 21(3), 1994, pp. 597-601

Abstract

The syndecans are a family of four cell surface heparan sulfate proteoglycans in vertebrates that mediate a variety of cell behaviors, including cell adhesion and the action of growth factors. Their core proteins contain conserved transmembrane and cytoplasmic domains but divergent extracellular regions in which only the glycosaminoglycan attachment sites are conserved. By extensive PCR analyses based on the conserved sequences, we find only four syndecan-related sequences in the mouse. These correspond to the previously described core proteins of syndecan proteoglycans from other vertebrates. We have mapped the genes forsyndecan-2 to chromosome 15, syndecan-3 to chromosome 4, and syndecan-4 to chromosome 2 in the mouse. Together with the previous localization of the gene for syndecan-1 to chromosome 12, these data establish that the four syndecan genes are dispersed on different chromosomes andthat each syndecan gene is located near a member of the nye gene family. Synd1 is next to Nmyc, Synd2 close to myc, Synd3 near Lmyc, and Synd4 on the same chromosome as Bmyc. The physical relationship between the members of these two gene families appears to be ancient and conserved after the two genome duplications thought to have occurred duringvertebrate evolution. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 23:12:52