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Titolo:
INHIBITORY EFFECTS OF BLACK TEA, GREEN TEA, DECAFFEINATED BLACK TEA, AND DECAFFEINATED GREEN TEA ON ULTRAVIOLET-B LIGHT-INDUCED SKIN CARCINOGENESIS IN 7,12-DIMETHYLBENZ[A]ANTHRACENE-INITIATED SKH-1 MICE
Autore:
WANG ZY; HUANG MT; LOU YR; XIE JG; REUHL KR; NEWMARK HL; HO CT; YANG CS; CONNEY AH;
Indirizzi:
RUTGERS STATE UNIV,COLL PHARM,DEPT CHEM BIOL & PHARMACOGNOSY,CANC RESLAB,POB 789 PISCATAWAY NJ 08855 RUTGERS STATE UNIV,COLL PHARM,DEPT CHEM BIOL & PHARMACOGNOSY,CANC RESLAB PISCATAWAY NJ 08855 RUTGERS STATE UNIV,COLL PHARM,DEPT PHARMACOL & TOXICOL PISCATAWAY NJ 08855 RUTGERS STATE UNIV,COOK COLL,DEPT FOOD SCI NEW BRUNSWICK NJ 08901
Titolo Testata:
Cancer research
fascicolo: 13, volume: 54, anno: 1994,
pagine: 3428 - 3435
SICI:
0008-5472(1994)54:13<3428:IEOBTG>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED COLON CARCINOGENESIS; MAMMARY-GLAND TUMORIGENESIS; POLYPHENOL FRACTION; CAFFEINE CONSUMPTION; TUMOR INITIATION; DRINKING-WATER; HAIRLESS MICE; SENCAR MICE; A/J MICE; ANTIOXIDANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
Z.Y. Wang et al., "INHIBITORY EFFECTS OF BLACK TEA, GREEN TEA, DECAFFEINATED BLACK TEA, AND DECAFFEINATED GREEN TEA ON ULTRAVIOLET-B LIGHT-INDUCED SKIN CARCINOGENESIS IN 7,12-DIMETHYLBENZ[A]ANTHRACENE-INITIATED SKH-1 MICE", Cancer research, 54(13), 1994, pp. 3428-3435

Abstract

In a previous study (Z. Y. Wang et al., Cancer Res., 52: 1162-1170, 1992), we found that administration of a water extract of green tea leaves as the sole source of drinking fluid inhibited ultraviolet B light(UVB)induced carcinogenesis in SKH-1 mice previously initiated with 7,12-dimethylbenz[a]anthracene (DMBA). In the present study, we compared the effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on UVB-induced skin carcinogenesis in DMBA-initiated SKH-1 mice. A 1.25% water extract of each kind of tea leaf (1.25 g tea leaf/100 ml water) was prepared by passing 4 liters of hot waterthrough 50 g of tea leaves in a Bunn tea brewing machine. The mean concentrations of solids in multiple samples of 1.25% black tea, green tea, decaffeinated black tea, and decaffeinated green tea analyzed during the course of this study were 4.23, 3.94, 3.66, and 3.53 mg/ml, respectively. These concentrations of tea solids are similar to those present in tea brews ingested by humans. Female SKH-1 mice were treated topically with 200 nmol of DMBA, followed 3 weeks later by irradiation with 30 mJ/cm(2) of UVB twice weekly for 31 weeks. UVB-induced formation of skin tumors was markedly inhibited by oral administration of 0.63 or 1.25% black tea, green tea, decaffeinated black tea, or decaffeinated green tea as the sole source of drinking fluid 2 weeks prior to and during 31 weeks of UVB treatment. Administration of each of the eight tea preparations not only inhibited the number of tumors, but tumorsize was also markedly decreased. Histopathological examination of each tumor showed that oral administration of the eight tea preparationshad a marked inhibitory effect on the formation of UVB-induced keratoacanthomas and carcinomas. Administration of 1.25% black tea, green tea, decaffeinated black tea, or decaffeinated green tea inhibited the number of keratoacanthomas per mouse by 79, 78, 73, or 70%, respectively, and the number of carcinomas per mouse was inhibited by 93, 88, 77,or 72%, respectively. In summary, administration of black tea was comparable to green tea as an inhibitor of UVB-induced skin carcinogenesis in DMBA-initiated SKH-1 mice. Oral administration of decaffeinated black tea or decaffeinated green tea also had a marked inhibitory effect on UVB-induced skin carcinogenesis in DMBA-initiated SKH-1 mice, butthese tea preparations were slightly less effective than the regular teas at the high dose level.

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Documento generato il 05/12/20 alle ore 01:52:19