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Titolo:
ADENOSINE ACTS AS AN ENDOGENOUS ACTIVATOR OF THE CELLULAR ANTIOXIDANTDEFENSE SYSTEM
Autore:
MAGGIRWAR SB; DHANRAJ DN; SOMANI SM; RAMKUMAR V;
Indirizzi:
SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL,POB 19230 SPRINGFIELD IL 62794 SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL SPRINGFIELD IL 62794
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 2, volume: 201, anno: 1994,
pagine: 508 - 515
SICI:
0006-291X(1994)201:2<508:AAAAEA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPERFUSION INJURY; SUPEROXIDE-DISMUTASE; MYOCARDIAL INJURY; FREE-RADICALS; ISCHEMIA; RECEPTOR; RELEASE; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Maggirwar et al., "ADENOSINE ACTS AS AN ENDOGENOUS ACTIVATOR OF THE CELLULAR ANTIOXIDANTDEFENSE SYSTEM", Biochemical and biophysical research communications, 201(2), 1994, pp. 508-515

Abstract

Oxygen free radicals have been implicated in the pathogenesis of ischemic cell injuries. These free radicals are normally scavenged by antioxidant enzymes. Adenosine is normally released during ischemia and protects against ischemic injuries by interacting with adenosine receptors (ARs). The mechanism underlying its cytoprotective action is unclear. In this report, we provide evidence that activation of a unique A,AR in rat basophilic leukemia cells (RBL-2H3) leads to a 2 to 3 fold increase in activity of superoxide dismutase, catalase and glutathione peroxidase and also increases in the activity of glutathione reductase. Similar increases in enzyme activity were elicited in bovine and human endothelial cells, rat cardiac myocytes and smooth muscle cells. Increases in enzyme activity were attenuated by theophylline (an antagonist of the A(3)AR) and by pertussis toxin, implicating a role of A(3)AR/G(i) protein in the activation. Importantly, activation of the A(3)ARdecreased the degree of lipid peroxidation in these cells. These dataprovide strong evidence that the cytoprotective action of adenosine during ischemic cell injuries is mediated, at least in part, via a novel mechanism - activation of the cellular antioxidant enzymes. (C) 1994Academie Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 11:14:40