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Titolo:
CONTRASTING ACTIONS OF COCAINE, LOCAL-ANESTHETIC AND TETRODOTOXIN ON DISCHARGE PROPERTIES OF RAT AORTIC BARORECEPTORS
Autore:
ANDRESEN MC; BRODWICK M; YANG MY;
Indirizzi:
OREGON HLTH SCI UNIV,DEPT PHYSIOL PORTLAND OR 97201 UNIV TEXAS,MED BRANCH,DEPT PHYSIOL & BIOPHYS GALVESTON TX 77550
Titolo Testata:
Journal of physiology
fascicolo: 2, volume: 477, anno: 1994,
pagine: 309 - 319
SICI:
0022-3751(1994)477:2<309:CAOCLA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BARORECEPTORS; BLOOD-PRESSURE; NERVE-FIBERS; INVITRO; NOREPINEPHRINE; MECHANISMS; NEURONS; SENSITIVITY; MODULATION; CURRENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Andresen et al., "CONTRASTING ACTIONS OF COCAINE, LOCAL-ANESTHETIC AND TETRODOTOXIN ON DISCHARGE PROPERTIES OF RAT AORTIC BARORECEPTORS", Journal of physiology, 477(2), 1994, pp. 309-319

Abstract

1. Effects of cocaine, lignocaine, benzocaine and tetrodotoxin (TTX) on the simultaneously measured pressure- and diameter-discharge frequency relations of single fibre baroreceptors were compared in rat in vitro aortic arch-aortic nerve preparations. 2. Between 1 and 10 mu M, cocaine produced selective increases in the pressure threshold shiftingthe pressure-response curve without altering the gain or threshold frequency. At near-blocking concentrations, gain was depressed as well. Cocaine experiments were done in nitroprusside (NP, 1 mu M). Neither NP or NP with cocaine altered diameter (P > 0.36). 3. Lignocaine (at >10 mu M) and benzocaine (at >100 mu M) shifted pressure-response curvesto higher pressures and generally depressed discharge by increasing pressure threshold and decreasing maximum discharge frequency (P < 0.05). Gain decreased and threshold frequency increased at higher concentrations. Diameter was unaffected by lignocaine or benzocaine (P > 0.14). 4. TTX increased thresholds and discharge frequencies at threshold but did not shift pressure-discharge curve locations. This produced superimposable discharge curves with changes occurring as losses of discharge points in the threshold region. Diameter was unaffected by TTX (P> 0.80). 5. The contrasting patterns of effects between TTX and localanaesthetics suggest that blockade of TTX-sensitive sodium channels alone may not be responsible for the effects of cocaine, Lignocaine andbenzocaine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:47:13