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Titolo:
CHARACTERIZATION OF INSULINS AND PROGLUCAGON-DERIVED PEPTIDES FROM A PHYLOGENETICALLY ANCIENT FISH, THE PADDLEFISH (POLYODON SPATHULA)
Autore:
NGUYEN TM; MOMMSEN TP; MIMS SM; CONLON JM;
Indirizzi:
CREIGHTON UNIV,SCH MED,CTR REGULATORY PEPTIDE OMAHA NE 68178 CREIGHTON UNIV,SCH MED,CTR REGULATORY PEPTIDE OMAHA NE 68178 UNIV VICTORIA,DEPT BIOCHEM & MICROBIOL VICTORIA V8W 3P6 BC CANADA KENTUCKY STATE UNIV,AQUACULTURE RES CTR FRANKFORT KY 40601
Titolo Testata:
Biochemical journal
, volume: 300, anno: 1994,
parte:, 2
pagine: 339 - 345
SICI:
0264-6021(1994)300:<339:COIAPP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCAGON-LIKE PEPTIDE; BOWFIN AMIA-CALVA; PREPROINSULIN; GENES; EVOLUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
T.M. Nguyen et al., "CHARACTERIZATION OF INSULINS AND PROGLUCAGON-DERIVED PEPTIDES FROM A PHYLOGENETICALLY ANCIENT FISH, THE PADDLEFISH (POLYODON SPATHULA)", Biochemical journal, 300, 1994, pp. 339-345

Abstract

The North American paddlefish, Polyodon spathula (Order Acipenseriformes) is an extant representative of a group of primitive Actinopterygian (ray-finned) fish that probably shared a common ancestor with present-day teleosts. Two molecular forms of insulin which differ by a single amino acid substitution, His or Asp at position 15 of the A chain, were isolated from the pancreas of the paddlefish. Paddlefish insulinsshow greatest structural similarity to insulin from the garfish (order Lepisosteiformes) and resemble mammalian insulins more strongly thando insulins from taleost fish. The primary structures of several proglucagon-derived peptides, two molecular forms of glucagon which differby the single amino acid substitution Arg(18)-->Ser, acid glucagon-like peptide, have been less well conserved during evolution. The paddlefish glucagons contain 31 amino acid residues, rather than the usual 29, and show several structural features, such as Met(5), Glu(24) and Gly(29), not previously observed in glucagons from other species. In spite of considerable differences in structure between paddlefish and mammalian glucagons (10 or 11 amino acid substitutions), both paddlefishglucagons are equally as effective as bovine glucagon in stimulating glycogenolysis in dispersed hepatocytes from the teleost fish Sebastescaurinus (rockfish). However, the substitution Arg(18)-->Ser in the paddlefish glucagon results in a 6-fold decrease in potency in this system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:48:14